Infective endocarditis: prognosis and management

Question 1

what are the poor prognostic factors of infective endocarditis ?

Answer 1

Staphylococcus aureus infection

prosthetic valve

negative culture endocarditis

low complement levels

Question 2

Mortality of infective endocarditis according to organism of staphylococcus ?

Answer 2

30 percent

Question 3

Mortality of infective endocarditis according to organism of bowel organism ?

Answer 3

15 percent

Question 4

Mortality of infective endocarditis according to organism of strep?

Answer 4

5 percent

Question 5

British National Formulary suggested antibiotic therapy empirically/ blind (unknown organism ) for NATIVE VALVE ?

Answer 5

amoxicillin,
consider adding low-dose gentamicin

Question 6

British National Formulary antibiotic therapy empirically/ blind (unknown organism ) for prosthetic VALVE ?

Answer 6

vancomycin + rifampicin + low-dose gentamicin

Question 7

British National Formulary antibiotic therapy empirically/ blind (unknown organism ) for native VALVE for PENCILLIN allergic / MRSA / SEVERE sepsis?

Answer 7

vancomycin + low-dose gentamicin

Question 8

British National Formulary antibiotic therapy for
Native valve endocarditis caused by staphylococci ?

Answer 8

Flucloxacillin

Question 9

British National Formulary antibiotic therapy for :
Native valve
staphylococci + penicillin allergic / MRSA ?

Answer 9

vancomycin + rifampicin

Question 10

British National Formulary antibiotic therapy for
prosthetic valve endocarditis
by staphylococci ?

Answer 10

Flucloxacillin + rifampicin + low-dose gentamicin

Question 11

British National Formulary antibiotic therapy for
prosthetic valve endocarditis
by staphylococci
PENCILLIN ALLERGY / MSRA ?

Answer 11

vancomycin + rifampicin + low-dose gentamicin

Question 12

antibiotic therapy for Endocarditis caused by fully-sensitive streptococci (e.g. viridans)

Answer 12

Benzylpenicillin

Question 13

antibiotic therapy for Endocarditis caused by fully-sensitive streptococci (e.g. viridans)
if penicillin allergy ?

Answer 13

vancomycin + low-dose gentamicin

Question 14

abs therapy Endocarditis caused by less sensitive streptococci

Answer 14

Benzylpenicillin + low-dose gentamicin

Question 15

abs therapy Endocarditis caused by less sensitive streptococci
if penicillin allergic ?

Answer 15

vancomycin + low-dose gentamicin

Question 16

Indications for surgery in infective endocarditis ?

Answer 16

severe valvular incompetence

aortic abscess (often indicated by a lengthening PR interval)

infections resistant to antibiotics/fungal infections

cardiac failure refractory to standard medical treatment

RECURRENT emboli after antibiotic therapy