ANP/BNP

Question 1

Where is ANP secreted?

Answer 1

secreted mainly from myocytes of right atrium and ventricle in response to increased blood volume
(It is also secreted from the left)

Question 2

ANP degraded by

Answer 2

endopeptidases

Question 3

Actions of ANP?

Answer 3

promotes excretion of sodium
lowers BP
antagonises actions of angiotensin II, aldosterone

Question 4

Actions of BNP ?

Answer 4

Vasodilation
And natriuresis

suppresses both sympathetic tone and the renin-angiotensin-aldosterone system

Question 5

Which drugs stops the degradation of ANP and BNP

Answer 5

neprilysin inhibitor, sacubitril, in combination with the angiotensin II receptor blocker, valsartan

Question 6

B-type natriuretic peptide (BNP) is a hormone produced mainly by the?

Answer 6

left ventricular myocardium in response to strain

Question 7

false positive pro-bnp?

Answer 7

chronic kidney disease.

Question 8

Causes of Low BNP

Answer 8

Obesity
Diuretics
ACE inhibitors
Beta-blockers
Angiotensin 2 receptor blockers

Question 9

is BNP a good prognostic factor ?

Answer 9

yes

Question 10

which predictive value for pro-BNP can we rely on ?

Answer 10

NRGATIVE PREDICTIVE VALUE