Infectious Rabies

Question 1

Rapidly progressive acute infectious disease of CNS

Rhabdoviridae Lyssavirus

Answer 1

Rabies

Question 2

Rabies forms

Answer 2

Encephalytic

Paralytic

Question 3

Dogs cats bats cattle racoons skunk fox

Worldwide most common: dogs

North america: bats silver haired tricolored

Answer 3

Vectors

Question 4

Microglial nodules with mononuclear inflamm infiltration

Answer 4

Babes nodules

Question 5

Most characteristic pathologic finding
Eosinophilic cytoplasmic inclusions in
Purkinje of cerebellum
Pyramidal of hippocampus

Answer 5

Negri body

Question 6

Earliest neuro sx

Answer 6

Paresthesia and

Pain on site

Question 7

Furious form
80%

Fever confusion hallucination combativeness and seizure

ANS dysfunction common
hypersalivation

water phobia

Answer 7

Encephalitic

Question 8

20% muscle weakness

Quadriparesis

Answer 8

Paralytic

Question 9

Dx

Answer 9

CSF - mild mononuclear cell pleocytosis with mildly elevated protein level
MRI
EEG

Question 10

Skin biopsy at

Answer 10

Cutaneous nerve at base of hair follicle at nape of neck (predilection)

Question 11

Virus specific neutralizing antibodies in CSF suggest

Answer 11

Rabies encephalitis

Question 12

Tx

Answer 12

No established

Question 13

All previously unvaccinated persons must be given

Answer 13

RIG no later than 7 days

Do not give if previously vaccinated

Question 14

Dose of RIG

Answer 14

RIG 20 IU infiltrated at site of bite

Remaining IM at site distant of bite

Question 15

Pregnancy

Answer 15

Not CI to rabies vaccine

Question 16

If human RIG not available give

Answer 16

Equine 40IU/kg

Question 17

Lyssa virus

Answer 17

Rabies

Question 18

Pathogenesis of hydrophobia

Answer 18

Contraction of pharynx

Laryngospasm/Airway

Question 19

Genital complication in rabies

Answer 19

Priapism

Question 20

Urban rabies

Answer 20

Dog and cats

Question 21

Sylvatic rabies

Answer 21

Wild: skunk, racoon, bat

Question 22

Monkeys are assoc

Answer 22

Ebola

HIV

Question 23

Most common cause of death in rabies

Answer 23

Respiratory failure

Question 24

Most common bacteria transmitted by humans

Answer 24

Eikenella corrodens

Question 25

Milwaukee protocol for human rabies

Answer 25

Coma (ketamine) dissociative anesthetic

Amantadine

Question 26

Cat scratch disease

Answer 26

Bartonella henslae

mucocutaneous lymph

Question 27

Cat feces

Answer 27

Toxoplasma

Question 28

Cat bite

Answer 28

Pasteurella multocidans

Question 29

Eikenella causes

HACEK

Answer 29

infectious endocarditis

Question 30

Neuron most sensitive to hypoxia

Answer 30

CA1 pyramidal

Question 31

Rabbit bite

Answer 31

Tularemia