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Medicine > Infectious Rabies > Flashcards

Infectious Rabies Flashcards

1
Q

Rapidly progressive acute infectious disease of CNS

Rhabdoviridae Lyssavirus

A

Rabies

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2
Q

Rabies forms

A

Encephalytic

Paralytic

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3
Q

Dogs cats bats cattle racoons skunk fox

Worldwide most common: dogs

North america: bats silver haired tricolored

A

Vectors

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4
Q

Microglial nodules with mononuclear inflamm infiltration

A

Babes nodules

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5
Q

Most characteristic pathologic finding
Eosinophilic cytoplasmic inclusions in
Purkinje of cerebellum
Pyramidal of hippocampus

A

Negri body

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6
Q

Earliest neuro sx

A

Paresthesia and

Pain on site

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7
Q

Furious form
80%

Fever confusion hallucination combativeness and seizure

ANS dysfunction common
hypersalivation

water phobia

A

Encephalitic

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8
Q

20% muscle weakness

Quadriparesis

A

Paralytic

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9
Q

Dx

A

CSF - mild mononuclear cell pleocytosis with mildly elevated protein level
MRI
EEG

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10
Q

Skin biopsy at

A

Cutaneous nerve at base of hair follicle at nape of neck (predilection)

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11
Q

Virus specific neutralizing antibodies in CSF suggest

A

Rabies encephalitis

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12
Q

Tx

A

No established

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13
Q

All previously unvaccinated persons must be given

A

RIG no later than 7 days

Do not give if previously vaccinated

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14
Q

Dose of RIG

A

RIG 20 IU infiltrated at site of bite

Remaining IM at site distant of bite

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15
Q

Pregnancy

A

Not CI to rabies vaccine

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16
Q

If human RIG not available give

A

Equine 40IU/kg

17
Q

Lyssa virus

18
Q

Pathogenesis of hydrophobia

A

Contraction of pharynx

Laryngospasm/Airway

19
Q

Genital complication in rabies

20
Q

Urban rabies

A

Dog and cats

21
Q

Sylvatic rabies

A

Wild: skunk, racoon, bat

22
Q

Monkeys are assoc

23
Q

Most common cause of death in rabies

A

Respiratory failure

24
Q

Most common bacteria transmitted by humans

A

Eikenella corrodens

25
Q

Milwaukee protocol for human rabies

A

Coma (ketamine) dissociative anesthetic

Amantadine

26
Q

Cat scratch disease

A

Bartonella henslae

mucocutaneous lymph

27
Q

Cat feces

A

Toxoplasma

28
Q

Cat bite

A

Pasteurella multocidans

29
Q

Eikenella causes

HACEK

A

infectious endocarditis

30
Q

Neuron most sensitive to hypoxia

A

CA1 pyramidal

31
Q

Rabbit bite

Medicine (29 decks)

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