Cardiology 3 Flashcards
HF with reduced EF
<40%
Formerly systolic failure
HFrEF
HF with EF >/= 50%
Formerly diastolic hf
HFpEF
Causes of preserved EF
Pathologic hypertrophy Aging Endomyocardial disorder Restrictive cardio Fibrosis
Causes of high output states
Metabolic Thyrotoxicosis Nutritional disorder beri beri thiamine Excess blood flow requirement Systemic AV shunt Chronic anemia
Dec ventricular contraction
CAD, MI, myocarditis, dilated cardiomyopathy
Low EF
Systolic dysfunction
Nonconpliant ventricle Concentric LVH due to HTN restrictive cardiomyopathy LV overload due to AR, MR Normal to high EF + S4 gallop
Diastolic dysfunction
Cardiac disease without limitation of physical activity
Ordinary PA does not cause fatigue, palpitation, dyspnea or angina
No symptom with ordinary exertion
NYHA Class I
Cardiac disease with SLIGHT limitation of PA
Comfortable at rest
Ordinary PA results in fatigue, palpitation, dyspnea or angina
Ordinary activity causes symptoms
NYHA Class II
Cardiac disease resulting in MARKED limitation of PA
Comfortable at rest
Less than ordinary PA causes fatigue, palpitation, dyspnea or angina
Asymptomatic at rest
NYHA Class III
Cardiac disease with INABILITY to carry on any PA without discomfort
Anginal symptom even at rest
NYHA Class IV
Control of congestion Stabilize HR and BP -Candesartab (CHARM trial) -Digoxin and Nebivolol trial (ineffective) Improve exercise tolerance
HFpEF management
DOC to stabilize HR and BP in HFpEF
Candesartan
Cornerstone of therapy for HFrEF
RAAS blocker ACE/ARB
Beta blocker
Beta blockers that have beneficial effects to HFrEF
Carvedilol
Bisoprolol
Metoprolol succinate
HFrEF
Symptomatic NYHA II-IV give
ACEI or ARB + BB + Aldosterone antagonist (eple and spirono)
Avoid 4 drug tx
HFrEF drugs
Hydralazine Nitrate Ivabradine (Coralan) HR Na funny channels: Drug class Hyperpolarization Cyclic Activated Nucleotide-gated ch blockers Valsartan + Sacubitril ARNI Diuretics Aspirin
Endopeptidase inbitor
Angiotensin Receptor Neprilysin Inhibitor
Sacubitril
Nerve that transmits pain on MI
intercostobrachial nerve
TI-T4
Paroxysmal recurrent precordial or substernal chest pain causes by transient MI falls short of infarct
Angina pectoris
Most stable type of angina
Narrowing of CA atherosclerosis >75%
Transient chest pain precipitated by exertion, emotion, relieved by rest and vasodilator
Stable angina