Infectious Diseases Flashcards
what are main causes of infectious cardiac disease?
implanted devices, pre-procedural prophylaxis, procedures, type of device
what microorganisms cause infectious diseases?
staph aureus, staph epidermis which act as biofilms
what are biofilms
slow growing vegetations that can cause infection over time
what are some non-specific symptoms that present with infection?
fever, pain, swelling, redness, discharge, haematoma
what ix if carried out if someone presents with non-specific symptoms of infection?
blood cultures=3 sets of bloods before Antibis given
gram film=distinguish between staph a & staphylococcus
echo= shows vegetations on valves
what are the classes of infective endocarditis
subacute and acute
what is infective endocarditis
infection of endothelium of heart valves
True/False…
infective endocarditis is typically right sided
False…
typically left sided (mitral & aortic
when does right sided infective endocarditis (usually tricuspid valve) usually present?
in PWIDs
what microorganism is usually responsible for causing infective endocarditis in PWIDs
staph a / bacillus serious
what is the pathophysiology of endocarditis
heart valve damage > turbulent blood flow > platelet & fibrin deposits > bacteraemia deposits in fibrin > vegetations that digest heart valves
what are triggers of endocarditis?
valve abnormalities, prosthetic valves, PWIDs, IV lines
what are presenting symptoms of acute infective endocarditis
sepsis, cardiac failure
what are presenting symptoms of subacute endocarditis
fever, malaise, wt loss
what are some signs of endocarditis
murmur, pyrexia, clubbing, splinter haemorrhages, roth spots, osler’s nodes, janeway lesions, haematuria
which out of roth spots, osler’s nodes and janeway lesions are painful?
Osler’s Nodes
what is haematuria
blood cells leak into urine
why does clubbing occur
in cardiothoracic disease when there isn’t enough O2 in blood e.g. bronchiectasis
how to ix infective endocarditis
echo etc and use DUKE’S criteria
tx dependent on cause for infective endocarditis
native valve: amoxicillin/ gent
prosthetic valve: IV vancomycin & gent
PWIDs: flucloxacillin IV
what drug is added to prosthetic valve tx 3-5 days after vancomycin & gent?
Rifampicin
what antibi for staph aureus
IV flucloxacillin
what antibi for viridian’s streptococci
IV benzylpenicillin & gent
what antibi for for enterococci
IV amoxi & gent
what antibi for staph epidermis
IV vancomycin & gent & rifampicin
what tx should be pursued if Antibis do not work
surgery
what are some complications of infective endocarditis
acute valvular incompetence, cardiac failure, fistula, abscess, pericarditis, emboli
what are 2 sub-types of infective endocarditis
prosthetic valve endocarditis, PWID endocarditis