Infectious disease and infection control Flashcards
What is an infection?
Infection is a process of tissue invasion by microorganisms, characterized by multiplication of these microorganisms in the body of the host to produce disease.
What is cross-infection?
Cross infection implies transmission of infection between patients as well as patients and health care professionals.
what is community acquired infections?
That may be present at the time of admission or a visit to a hospital or incubating at that time.
what is a Health-Care-Associated Infections?
That could be induced from a source outside the patient’s body (exogenous) or from within the patient’s own body (autogenous) after a visit or admission to a hospital or health care centre.
how is Herpes simplex type 1 contracted?
Herpes simplex type 1 spread by infected saliva
what is the incubation period for Herpes simplex type 1?
2-12 days
what is the clinical features of herpes simplex type 1?
- Orolabialis infection
- sore throat
- fever
- vesicles on pharynx
- buccal mucosa, gingiva & tongue which spreads to lips and face
- lymphadenopathy
- recurrence
how is herpes simplex types 2?
Herpes simplex type 2 spread by sexual contact.
how does herpes simplex affect the skin?
- hsv-1 or hsv-2
- herpetic whitlow
- primary infections
how does herpes simplex affect the eye?
- usually hsv-1
- corneal involvement is serious since it may cause blindness
what is complications of herpes simplex?
- encephalitis - affects temporal lobes
- neonatal - serious since mortality is 60 % due to transfer of HSV-2 during parturition
- indication for a caesarian section
- erythema multiforme
- eczema herpeticum
what is the treatment for herpes simplex?
Acyclovir, Valacylcovir
what is the clinical features of varicella zoster virus?
- preceded by radicular pain and hyperaesthesia of overlying skin
- rash - unilateral, dermatomal
- intense erythema which rapidly become vesicles whichcrust
- oral, palatal or pharyngeal involvement if Trigeminal nerve affected
- ocular involvement causes keratitis or uveitis which may result in blindness
- Ramsay-Hunt Syndrome – reactivation of VZV in the geniculate ganglion of the VII cranial nerve
what is the complication of herpes zoster?
- post-herpetic neuralgia
- neurological e.g. Meningitis
what is the treatment for herpes zoster?
Acyclovir - reduces pain / accelerates healing (no effect on post-herpetic neuralgia)
what is the incubation period Epstein-Barr virus?
4-14 days
what is clinical features of Epstein-Barr virus?
- anorexia, malaise, fever
- sore throat
- cervical lymphadenopathy
- macular rash n.b. Ampicillin
- tonsillitis with white exudate
- palatal petechiae
- palpable spleen
- jaundice (10%)
- Infectious mononucleosis
what is the complication of Epstein-Barr virus?
- hepatitis
- respiratory obstruction
- ruptured spleen (rare - told to avoid contact sports)
what is the diagnosis for Epstein-Barr virus?
Monospot test
what is the incubation period of Varicella zoster virus?
14-16 days
what are the clinical features of Varicella zoster virus?
- rash - appears in crops and progresses from macule to papule to vesicle
- starts on trunk or scalp
- spreads to limbs and face
- vesicles dry and crust
- pruritis
- shallow ulcers on mm’s
what are the complications Varicella zoster virus?
- cellulitis or impetigo
- pneumonia
- neurological e.g. Acute cerebellar ataxia, Reye’s syndrome
- congenital abnormalities
what are the treatments for varicella zoster virus?
- Antihistamines
- Acyclovir (severe cases/complications)
What is the incubation period for mumps?
16-21 day
how is mumps spreaded?
Spread by droplets from saliva and nasopharyngeal secretions
what is the clinical features of mumps?
- asymptomatic in 40%
- fever, malaise, “angle pain”
- enlargement of one or both parotids
- earache and displacement of earlobe
- parotid papillae inflamed
- difficulty in swallowing
- submandibular glands may be affected
what are the complications of mumps?
- neurological - aseptic meningitis, encephalitis
- orchitis - 20-25% in post pubertal
- non-parotid mumps - ovaries, thyroid, pancreas, breasts