infectious and inflammatory disorder of urinary tract Flashcards
UTIs
most common infection and second most common bacterial disease in women
Causes
- E.coli = most common (proximity to anus)
- Candida albicans = second most common –> indwelling catheter or asymptomatic colonization (also in obese)
- fungal and parasitic = uncommon
classification of UTI
Location upper = renal parenchyma, pelvis, ureters (pyeloephritis)
Location lower = bladder (cystitis) and urethra (urethritis)
Systemic spread = urosepsis (life threatening)
Uncomplicated = bladder only
Complicated = occur w/ struc or func prob in whole urinary tract
Sterility of urinary tract
Defense mechanisms
Usually sterile above urethra
Defense
- complete emptying with void
- ureterovesical junction competence
- ureteral peristalsis propels urine to bladder
- acidic pH (under 6)
- high urea
- glycoproteins (inhibit bacterial growth)
Risk factors for UTI
obstruction retention renal impairments foreign bodies anatomic factors comprised immune response functional disorders other
Entrance of pathogens to form UTIs
Microbes from perineum ascend urethra
- GI tract: G- bacteria
- contributing factors = urologic instrumentation and sexual intercourse
Hematogenous transmission
HAI –> MOST COMMON ONE
- catheter –> E.coli or pseudomonas
- increased risk with longer stay
Lower urinary tract symptoms (LUTS)
Emptying
-hesitancy, intermittency, post-void dribble, urinary retention/ incomplete emptying, dysuria
Storage
-urinary frequency, urgencym incontinence, nocturia, nocturnal enuresis
Hematuria and/or cloudy
LUTS isn’t same as UTI
Upper urinary tract symptoms
flank pain, chills, fever
Other: fatigue, anorexia, or asymptomatic
Older adults (no classical manifestations) -nonlocalized abdominal discomfort, cognitive impairments, or generalized deterioration; often afebrile
Asymptomatic bacteria - colonization of bacteria in bladder; screen and treat with pregnancy
Diagnostic studies for UTIs
Initial: dipstick for nitrates, WBCs, and leukocyte esterase
Urine culture/sensitivity
History: -recurring UTIs (more than 2-3/ yr) -comlicated UTIs -CAUTIs or HAI UTIs UTI unreponsive to empiric therapy
Imaging: ultrasound or CT scan
UTI interprofessional care:
management (uncomplicated)
Reccurent UTI
Management
- patient teaching: have whole prescription
- adequate fluids
- drug therapy: phenazopyridine and antibiotics (empiric) for 3 days
Recurrent
- as above plus susceptibility testing and possibly suppressive or prophylactic antibiotics
- antibiotics for 7-14+ days
UTI intraprofessional care
drug therapy
DON’T NECESSARILY NEED TO KNOW
Uncomplicated or initial UTIs
- trimethoprim/sulfamethoxazole (TMP-SMX)
- Nitrofurantoin Cephalexin
- Fosfomycin
- Others: ampicillin, amoxicillin, or cephalosporins
Complicated: fluoroquinolones
Fungal: fluconazole
Urinary analgesic: phenazopyridine (azo dye)
Prevention of CAUTI
Avoid unncessary catheterizations remove indwelling catheter early aseptic technique hand hygiene gloves for catheter care
Evidence based clinical tool from ANA
Acute Pyelonephritis etiology and pathophysiology
inflammation of renal parenchyma and collecting system
- common: bacteria (E.coli, proteus, klebisella, or enterobacter from intestinal tract)
- other: fungi, protozoa, or viruses
Urosepsis - systemic infection from urologic source
Pyelonephritis: where and how it starts NOPE
Where
- initial colonization and infection of lower urinary tract from urethra
- starts in renal medulla, spreads to cortex
How
- preexisting factors: vesicoureteral reflux or dysfunction of lower urinary tract
- CAUTI in long-term care residents
- pregnancy-induced changes
Pyelonephritis manifestations NOPE
Classic: fever, chills, nausea, vomiting, malaise, flank pain
Other: dysuria, urgency, frequency
Costovertebral angle tenderness
Diagnostic studies of Pyelonephritis NOPE
Urinalysis: pyuria, bacteriuria, hematuria, WBC casts
Urine cultures and sensitivities
Blood cultures
decreased kidney func test
ultrasuond
CT scan –> preferred imaging study