Infectiouns Mononucleosis

Question 1

Infectious mononucleosis is also known as kissing disease which is caused by?

Answer 1

Epstein-Barr Virus

Question 2

What WBC is infected in EBV?

a. Neutrophil
b. T cell
c. B cell
d. NK Cell

Answer 2

c

Question 3

What is the main MOT for EBV?

Answer 3

Respiratory secretion

Question 4

EBV belong to the family of what virus?

a. Poxvidiriae
b. Herpesviridae
c. Hepadnaviridae
d. Retroviridae

Answer 4

b

Question 5

Infants usually has asymptomatic infection from mononucleosis

T or F

Answer 5

T

Question 6

Infectious mononucleosis:

Heterophile antibody test: Positive
IgM anti-VCA: low titer
Liver enzymes: Elevated
Differential count: Increased

Which of the following is wrong?

Answer 6

IgM Anti-VCA should be high titer

Question 7

Atypical lymphocytes that is usually found in infectious mononucleosis?

Answer 7

Downey cells

Question 8

Broad class of antibodies that is stimulated by one antigen and react with an entirely unrelated surface antigen present on cells from different organism.

a. Heterophile antibodies
b. Autoantibodies
c. Hetero-antibodies
d. Allo-antibodies

Answer 8

a

Question 9

A titer of ___________ is clinically significant in patients suspected with IM

a. 1:46 or greater
b. 1:56 or lesser
c. 1:46 or lesser
d. 1:56 or greater

Answer 9

d

Question 10

This RBCs is found on many species including horse, sheep, dog, cat, fowls and some bacteria

a. Horssman antigen
b. Forssman antigen
c. Lorssman antigen
d. Porssman antigen

Answer 10

b

Question 11

Heterophile antibodies (IgM) appears during the acute phase of IM but the antigen that stimulates it remain unknown

T or F

Answer 11

T

Question 12

Paul Bunnel test uses simple dilutions of patient’s serum to which small amounts of ______RBCs are added

a. Dog
b. Horse
c. Sheep
d. Cow

Answer 12

c

Question 13

In Paul Bunnel Test

Agglutination = Presence of heterophile antibodies
No Agglutination = Absence of heterophile antibodies

T or F

Answer 13

T

Question 14

In Paul Bunnel Test, no agglutination could be an indication of a false positive

T or F

Answer 14

F

False negative

Question 15

In Monospot test, Agglutination of ____ RBCs by heterophile antibodies

This RBCs exhibits antigen directed against Forssman and IM antibodies

a. Dog
b. Horse
c. Sheep
d. Cow

Answer 15

b

Question 16

Classic differential test to distinguish between heterophile sheep cell agglutinins in human serum due to Forssman antigen, serum sickness, and
infectious mononucleosis

a. Monospot Test
b. Davidsohn Differential test
c. Paul Bunnel Test
d. EBV serological panel

Answer 16

b

Question 17

Davidsohn Differential test:

Adsorbed by Guinea Pig Kidney Cells: (yes)
Adsorbed by beef Erythrocytes: (No)

a. Forssmann antibody
b. Infectious Mononucleosis
c. Serum Sickness

Answer 17

a

Question 18

Davidsohn Differential test:

Adsorbed by Guinea Pig Kidney Cells: (No)
Adsorbed by beef Erythrocytes: (Yes)

a. Forssmann antibody
b. Infectious Mononucleosis
c. Serum Sickness

Answer 18

b

Question 19

Davidsohn Differential test:

Adsorbed by Guinea Pig Kidney Cells: (Yes)
Adsorbed by beef Erythrocytes: (Yes)

a. Forssmann antibody
b. Infectious Mononucleosis
c. Serum Sickness

Answer 19

c

Question 20

EBV serological panel is applied to:
→ Asymptomatic patients
→ Heterophile Ab-negative
→ Immunocompetent individuals

Which of the following does not belong?

Answer 20

Immunocompetent should be immunosuppressed

Question 21

What are the EBV-infected B cells express “new” antigens encoded by the virus?

Answer 21

Vira Capsid Antigen (VCA)
Early Antigen (EA)
Epstein Barr Nuclear Antigen (EBNA)

Question 22

Viral Capsid Antigen is found in the?

a. Nucleus
b. Ribosome
c. Cytoplasm
d. Membrane

Answer 22

c

Question 23

• IgM Anti-VCA is detectable during the early course of the infection (low titer and usually disappears after 2-4 months)
• IgG Anti-VCA is detectable within 4-7 days after the onset of signs and symptoms and persists for a long period perhaps lifetime

T or F

Answer 23

T

Question 24

Early antigen - Diffuse (EA-D) us usually found in the _____________ of B cells

a. Nucleus and Cytoplasm
b. Nucleus and membrane
c. Cytoplasm and membrane
d. Cytoplasm and Ribosome

Answer 24

a

Question 25

Early antigen - Resticted (EA-R) found as a mass only in?

a. Nucleus
b. Ribosome
c. Cytoplasm
d. Membrane

Answer 25

c

Question 26

→ Early Antigen – Diffuse (EA-D): IgG Anti EA-D is highly indicative of acute infection and reactivation
of latent infection

→ Early Antigen – Restricted (EA-R): IgG Anti EA-R is seen in very young children during the acute stage

T or F

Answer 26

T

Question 27

EBNA is found in?

a. Nucleus
b. Ribosome
c. Cytoplasm
d. Membrane

Answer 27

a

Question 28

Anti-EBNA is almost always present in serum containing anti-VCA (except during acute period) or in immunodeficient or immunosuppressed
individuals

T or F

Answer 28

T

Question 29

IgG anti-EBNA appears during the convalescent period

T or F

Answer 29

T

Question 30

When you have antibodies against EBNA, you have developed immunity against EBV.

T or F

Answer 30

T

Question 31

IgM anti-VCA: (-)
IgG anti-VCA: (-)
Anti EA-D: (-)
Anti EA-R: (-)
IgG anti-EBNA: (-)
Heterophile Ab: (-)

a. No previous exposure
b. Acute infection
c. Convalescence
d. Reactivation

Answer 31

a

Question 32

IgM anti-VCA: (+/-)
IgG anti-VCA: (+)
Anti EA-D: (+/-)
Anti EA-R: (+/-)
IgG anti-EBNA: (+)
Heterophile Ab: (+/-)

a. No previous exposure
b. Acute infection
c. Convalescence
d. Reactivation

Answer 32

d

Question 33

IgM anti-VCA: (+)
IgG anti-VCA: (+)
Anti EA-D: (+/-)
Anti EA-R: (-)
IgG anti-EBNA: (-)
Heterophile Ab: (+)

a. No previous exposure
b. Acute infection
c. Convalescence
d. Reactivation

Answer 33

b

Question 34

IgM anti-VCA: (-)
IgG anti-VCA: (+)
Anti EA-D: (-)
Anti EA-R: (-)
IgG anti-EBNA: (+)
Heterophile Ab: (-)

a. No previous exposure
b. Acute infection
c. Convalescence
d. Reactivation

Answer 34

c