Infectiouns Mononucleosis Flashcards
Infectious mononucleosis is also known as kissing disease which is caused by?
Epstein-Barr Virus
What WBC is infected in EBV?
a. Neutrophil
b. T cell
c. B cell
d. NK Cell
c
What is the main MOT for EBV?
Respiratory secretion
EBV belong to the family of what virus?
a. Poxvidiriae
b. Herpesviridae
c. Hepadnaviridae
d. Retroviridae
b
Infants usually has asymptomatic infection from mononucleosis
T or F
T
Infectious mononucleosis:
Heterophile antibody test: Positive
IgM anti-VCA: low titer
Liver enzymes: Elevated
Differential count: Increased
Which of the following is wrong?
IgM Anti-VCA should be high titer
Atypical lymphocytes that is usually found in infectious mononucleosis?
Downey cells
Broad class of antibodies that is stimulated by one antigen and react with an entirely unrelated surface antigen present on cells from different organism.
a. Heterophile antibodies
b. Autoantibodies
c. Hetero-antibodies
d. Allo-antibodies
a
A titer of ___________ is clinically significant in patients suspected with IM
a. 1:46 or greater
b. 1:56 or lesser
c. 1:46 or lesser
d. 1:56 or greater
d
This RBCs is found on many species including horse, sheep, dog, cat, fowls and some bacteria
a. Horssman antigen
b. Forssman antigen
c. Lorssman antigen
d. Porssman antigen
b
Heterophile antibodies (IgM) appears during the acute phase of IM but the antigen that stimulates it remain unknown
T or F
T
Paul Bunnel test uses simple dilutions of patient’s serum to which small amounts of ______RBCs are added
a. Dog
b. Horse
c. Sheep
d. Cow
c
In Paul Bunnel Test
Agglutination = Presence of heterophile antibodies
No Agglutination = Absence of heterophile antibodies
T or F
T
In Paul Bunnel Test, no agglutination could be an indication of a false positive
T or F
F
False negative
In Monospot test, Agglutination of ____ RBCs by heterophile antibodies
This RBCs exhibits antigen directed against Forssman and IM antibodies
a. Dog
b. Horse
c. Sheep
d. Cow
b
Classic differential test to distinguish between heterophile sheep cell agglutinins in human serum due to Forssman antigen, serum sickness, and
infectious mononucleosis
a. Monospot Test
b. Davidsohn Differential test
c. Paul Bunnel Test
d. EBV serological panel
b
Davidsohn Differential test:
Adsorbed by Guinea Pig Kidney Cells: (yes)
Adsorbed by beef Erythrocytes: (No)
a. Forssmann antibody
b. Infectious Mononucleosis
c. Serum Sickness
a
Davidsohn Differential test:
Adsorbed by Guinea Pig Kidney Cells: (No)
Adsorbed by beef Erythrocytes: (Yes)
a. Forssmann antibody
b. Infectious Mononucleosis
c. Serum Sickness
b
Davidsohn Differential test:
Adsorbed by Guinea Pig Kidney Cells: (Yes)
Adsorbed by beef Erythrocytes: (Yes)
a. Forssmann antibody
b. Infectious Mononucleosis
c. Serum Sickness
c
EBV serological panel is applied to:
→ Asymptomatic patients
→ Heterophile Ab-negative
→ Immunocompetent individuals
Which of the following does not belong?
Immunocompetent should be immunosuppressed
What are the EBV-infected B cells express “new” antigens encoded by the virus?
Vira Capsid Antigen (VCA)
Early Antigen (EA)
Epstein Barr Nuclear Antigen (EBNA)
Viral Capsid Antigen is found in the?
a. Nucleus
b. Ribosome
c. Cytoplasm
d. Membrane
c
- IgM Anti-VCA is detectable during the early course of the infection (low titer and usually disappears after 2-4 months)
- IgG Anti-VCA is detectable within 4-7 days after the onset of signs and symptoms and persists for a long period perhaps lifetime
T or F
T
Early antigen - Diffuse (EA-D) us usually found in the _____________ of B cells
a. Nucleus and Cytoplasm
b. Nucleus and membrane
c. Cytoplasm and membrane
d. Cytoplasm and Ribosome
a
