infections in pregnancy Flashcards
cheap torchesz
chickenpox hepatitis evenrything else sexually transmitted AIDS/HIV parvovirus toxoplasma gondii rubella cytomegalovirus perplex simplex virus syhlis zika
antenatal screening
general and targeted HBV HCV HV syphilis rubella IgG no childhood Hx of VZV
fetal varicella syndrome
skin scars, eye abnormalities, limb abnormalities, prematurity, cortical atrophy, spoor sphincter control etc. mainly between 12-28 weeks
neonatal varicella
dependant on timing on maternal chicken pox
if baby has time to acquire antibody from mother prior to birth
management of VZV exposure in pregnancy
seropositive - no action required
seronegative - can givee ZIG up for 10 days
advise to seek review if develop symptoms of VZV
if too late for ZIG can give prophylactic
parvovirus
asymptomatic, non specific flu to erythema rash
patients with underlying bone marrow dysfunction may get aplastic anaemia
transmitted vertically and by respiratory secretions
rash means no longer infectious
symptomatic presentation of parvovirus
flu like illness followed by rash usually In children
painful swollen joints
transient bone marrow suppression (aplastic crisis) in patients with underlying bone marrow disorders
IgG and IgM usually both positive
parvovirus implications for pregnancy
fetal loss
hydros fetalis
transient effusions
probably not teratogenic
syphilis caused by
treponema pallidum
treponemal specific tests
detects antibodies directed to antigens specific to T palladium
become reactive after infection with T pallidum
do not indicated the of infection for whether infection is active
syphlis serology
non-treponema tests - RPR, VDRL
measure disease activity and are reported as titre
high levels equate to more active disease
a four fold titre decrease after treatment suggests an adequate response to treatment
rapid plasma reagin RPR
gives a titre, useful for monitoring response to treatment
sensitivity varies according to disease stage
ventral diseases research laboratory VDRL
usually used only on CSF
treatment for syphilis
benzithine penicillin
garish herxheimer reaction
fever, chills’ malaise, hypertension, tachycardia
may precipitate uterine contractions and preterm labour
