Infection and immunology Flashcards
Patient has oral ulcers, genital ulcers, and anterior uveitis. Has erythema nodosum. Gets a DVT. What test is suggestive of the condition?
Pathergy test - pustule following needle prick
Behcet’s
Patient has blueberry muffin skin lesions, hepatosplenomegaly, and seizures. What’s the treatment?
IV ganciclovir (for CMV)
First treatment for uncomplicated falciparum malaria
Arthemether-lumefantrine
Treatment for severe falciparum malaria
IV artesunate
Main cause of neutropenic sepsis
Staph epidermis
Neutropenic sepsis prophylaxis
Fluoroquinolone e.g. ciprofloxacin
Neutropenic sepsis treatment
Piperacillin with tazobactam (tazocin)
Which test is not specific for syphilis and when does it become negative?
Non-treponemal
- RPR
- VDRL
Negative after treatment (months to couple of years)
Which test is specific for syphilis and when does it become negative?
Treponemal
- TP-EIA
- TPHA
Positive forever
When does type 1 necrotising fasciitis often occur?
Post-surgery in diabetics (caused by mixed anaerobes and aerobes)
What causes type 2 necrotising fasciitis?
Strep pyogenes
Which drug in diabetics is associated with necrotising fasciitis?
SGLT-2 inhibitors e.g. dapagliflozin
Most common site of necrotising fasciitis?
Perineum (Fournier’s gangrene)
Initial features of necrotising fasciitis?
Rapidly worsening cellulitis and really bad pain to light touch
Necrotising fasciitis management
Urgent surgical debridement referral
IV abx
Patient has red face, small aphthous ulcers on his left buccal mucosa. He also has a maculopapular erythematous rash on his upper trunk, red hands and folliculitis on his chest. His liver and spleen are just palpable and he has mild neck stiffness. What is the condition?
HIV seroconversion
Condition with macular rash over his body, including palms, soles and scalp, a few palpable lymph nodes in the groin and a small papular lesion on the glans of his penis.
Secondary syphilis
Gonorrhoea management
1) Single dose IM ceftriaxone (or single oral ciprofloxacin if sensitive)
2) Oral cefixime + oral azithromycin
Chlamydia management
7 days doxycycline
Tests for chlamydia and gonorrohoea in women: endocervical or vulvovaginal?
Vulvovaginal
