Infection and Immunity

Question 1

What are biofilms? What allows them to form?

Answer 1

Aggregate of MO’s adhering to each other on living/non living surfaces in the body. The production of EPS (exopolysaccharides) enables growth/protection as it make ALGINATE which inhibits the innate immune system

Question 2

What are the 4 degradative enzymes?

Answer 2

-Lecithinase, phospholipidase, hemolysin, leukocidin/streptolysin

Question 3

What does lecithinase do?

Answer 3

destroys lecithin/phosphatidylcholine

Question 4

What does phospholipase do?

Answer 4

Breaks down phospholipids

Question 5

What does leukocidin/streptolysin do?

Answer 5

lyse phagocytes and their granules

Question 6

What do hemolysins do?

Answer 6

Lyse erythrocytes

Question 7

What are the spreading factors? (for bacteria)

Answer 7

-Hyaluronidase, Collagenase, Streptokinase/staphylokinase, Neuraminidase

Question 8

What does hyaluronidase do?

Answer 8

cleaves hyaluronic acid= component of extracellular matrix=tissue penetration

Question 9

What does collagenase do?

Answer 9

-breaks down collagen in CT

Question 10

What does streptokinase/staphylokinase do?

Answer 10

convert plasminogen to fibrin= promoting digesting of clots= help bacteria spread

Question 11

What does streptokinase/staphylokinase do?

Answer 11

convert plasminogen to fibrin= promoting digesting of clots= help bacteria spread