Induction Agents Flashcards
1
Q
pKa
A
Propofol: 11 Thiopental: 7.6 Etomidate: 4 Ketamine: 7.5 Midazolam: 6.5
2
Q
pH in solution
A
Propofol: 6-8.5
Thiopental: 10.5
Etomidate: 8.1
Ketamine: 3.5-5.5
3
Q
Volume of distribution (L/kg)
A
Propofol: 4
Thiopental: 2.5
Etomidate: 3
Ketamine: 3
4
Q
Protein binding (%)
A
Propofol: 98
Thiopental: 80
Etomidate: 75
Ketamine: 25
5
Q
Clearance (ml/kg/min)
A
Propofol: 30-60
Thiopental: 3.5
Etomidate: 10-20
Ketamine: 17
6
Q
Racemic
A
Propofol: No
Thiopental: Yes
Etomidate: Yes
Ketamine: Yes (S+ & R- isomer, S+ 2-3x more potent)
7
Q
Dose (mg/kg)
A
Propofol: 1-2
Thiopental: 3-7
Etomidate: 0.3
Ketamine: 1-2 (IV), 5-10 (IM)
8
Q
Elimination ½ life (hours)
A
Propofol: 5-12
Thiopental: 6-15
Etomidate: 1-4
Ketamine: 2
9
Q
Metabolites
A
Propofol: inactive
Thiopental: active
Etomidate: inactive
Ketamine: active
