Analgesia Flashcards
1
Q
pKa
A
Morphine: 8 Fentanyl: 8.4 Alfentanil: 6.5 Remifentanil: 7.1 Pethidine: 8.7 Paracetamol: 9.5 Aspirin: 3.5
2
Q
Lipid Solubility (relative to morphine)
A
Morphine: 1 Fentanyl: 600 Alfentanil: 90 Remifentanil: 20 Pethidine: 30
3
Q
Potency (relative to morphine)
A
Morphine: 1 Fentanyl: 100 Alfentanil: 20 Remifentanil: 100 Pethidine: 0.1
4
Q
Volume of distribution (L/Kg)
A
Morphine: 3.5 Fentanyl: 4.0 Alfentanil: 0.6 Remifentanil: 0.3 Pethidine: 4.0
5
Q
Elimination ½ life (min)
A
Morphine: 170 Fentanyl: 190 Alfentanil: 100 Remifentanil: 10 Pethidine: 210
6
Q
Clearance (ml/min/kg)
A
Morphine: 16 Fentanyl: 13 Alfentanil: 6 Remifentanil: 40 Pethidine: 12
7
Q
Protein binding (%)
A
Morphine: 35 Fentanyl: 83 Alfentanil: 90 Remifentanil: 70 Pethidine: 60
8
Q
% unionised at pH 7.4
A
Morphine: 23 Fentanyl: 9 Alfentanil: 89 Remifentanil: 68 Pethidine: 5
