Inclusion body myopathy

Question 1

—— myositis is an inflammatory myopathy that involves abnormal folding of beta-amyloid and/or hyperphosphorylated tau protein in distal muscles.

Answer 1

Inclusion body myositis is an inflammatory myopathy that involves abnormal folding of beta-amyloid and/or hyperphosphorylated tau protein in distal muscles.

Question 2

Inclusion body myositis is often initially misdiagnosed as ——until a course of prednisone is completed with no improvement.

Answer 2

Inclusion body myositis is often initially misdiagnosed as polymyositis until a course of prednisone is completed with no improvement.

Question 3

Electron microscopy shows tubolofilamentous myofibril inclusions in —— myositis.

Answer 3

Electron microscopy shows tubolofilamentous myofibril inclusions in inclusion body myositis.

Question 4

(Sporadic/Hereditary)——-inclusion body myositis is the most common cause of inflammatory myopathy in people over age 65.

Answer 4

(Sporadic/Hereditary) Sporadic inclusion body myositis is the most common cause of inflammatory myopathy in people over age 65.

Question 5

In a Gomori trichrome stain,——– myositis reveals myofibers containing reddish granular rimmed vacuoles.

Answer 5

In a Gomori trichrome stain, inclusion body myositis reveals myofibers containing reddish granular rimmed vacuoles.

Question 6

The presence of cN1A antibody is associated with ——myositis.

Answer 6

The presence of cN1A antibody is associated with inclusion body myositis.

Question 7

Like in polymyositis, inclusion body myositis presents with an increased sarcolemmal expression of MHC (class I/class II) ——-antigens.

Answer 7

Like in polymyositis, inclusion body myositis presents with an increased sarcolemmal expression of MHC (class I/class II) class I antigens.

Question 8

Inclusion body myositis most commonly affects (women/men) ——- .

Answer 8

Inclusion body myositis most commonly affects (women/men) men.

Question 9

Inclusion body myositis is characterized by (slow/quick) ——–progressive deterioration of both distal and proximal muscles of the upper and lower extremities.

Answer 9

Inclusion body myositis is characterized by (slow/quick) slow progressive deterioration of both distal and proximal muscles of the upper and lower extremities.

Question 10

——–myositis responds poorly to steroids and immunosuppressive therapies.

Answer 10

Inclusion body myositis responds poorly to steroids and immunosuppressive therapies.

Question 11

There is a sporadic and hereditary form of——–myositis.

Answer 11

There is a sporadic and hereditary form of inclusion body myositis.