Gout

Question 1

(primary/secondary) gout may be caused by renal insufficiency leading to uric acid underexcretion.

Answer 1

Secondary

Question 2

Gout causes———acid crystal deposits in renal tubules, leading to urate nephropathy.

Answer 2

uric

Question 3

Podagra is acute gout of the ——– joint of the big toe

Answer 3

metatarsal-phalangeal

Question 4

———syndrome can occur as a sequelae of cancer, causing rapid cell turnover and uric acid overproduction leading to gout.

Answer 4

Tumor lysis

Question 5

Gout is caused by (underexcretion/overproduction) of uric acid in 90% of cases

Answer 5

underexcretion

Question 6

Febuxostat is indicated for ——- in chronic gout.

Answer 6

preventing flare-ups

Question 7

Gout typically affects (gender) — .

Answer 7

Men

Question 8

Gout is caused by precipitation of needle shaped, (negative/positive) ——- birefringent, monosodium urate crystals.

Answer 8

negative birefringent

Question 9

In gout, monosodium urate crystals appear (color) —— under perpendicular light.

Answer 9

blue

Question 10

Two non-steroidal anti-inflammatory drugs, ——- , are indicated in acute gout.

Answer 10

naproxen
and
indomethacin

Question 11

——-disease is a glycogen storage disorder associated with gout which causes underexcretion and overproduction of uric acid.

Answer 11

Von Gierke

Question 12

——- abuse is a risk factor for gout due to uric acid underexcretion.

Answer 12

Alcohol

Question 13

In gout, monosodium urate crystals appear (color)—— under parallel light.

Answer 13

yellow

Question 14

With the exception of ——- , most myeloproliferative disorders increase the risk of hyperuricemia and gout.

Answer 14

essential thrombocythemia

Question 15

Acute gout is primarily treated with medications from three drug classes:——– .

Answer 15

non-steroidal anti-inflammatory drugs
, 
glucocorticoids
, or 
colchicine
.

Question 16

Large meals or alcohol consumption may cause episodes of ——in patients with acute gout.

Answer 16

arthritis

Question 17

Although genetic predisposition is apparent, hyperuricemia attendant to (primary/secondary) gout is idiopathic in origin

Answer 17

primary

Question 18

——-is a xanthine analog medication indicated for preventing hyperuricemia in chronic gout.

Answer 18

Allopurinol

Question 19

Gout is caused by precipitation of ——-shaped, negative birefringent, monosodium urate crystals.

Answer 19

needle shaped

Question 20

—— are white, chalky, uric acid crystal aggregates which may appear in the external ear, olecranon bursa, or Achilles tendon of patients with gout.

Answer 20

Tophi

Question 21

The loop and——– categories of diuretics may cause hyperuricemia and are contraindicated in patients with gout.

Answer 21

thiazide