Important People

Question 1

Charles Scott Sherrington

Answer 1

• One of the “fathers of neuroscience”
• Worked with reflex pathways — demonstrated reciprocal innervation of muscles (antagonistic muscle is inhibited)
• Showed that local graded potential can sum

Question 2

Santiago Ramon y Cajal

Answer 2

• Discovered dendritic spines on hippocampal neurons (important for memory)
• Won Nobel Prize with Golgi for work on the structure of the nervous system
• Discovered growth cones

Question 3

Erwin Neher and Bert Sakmann

Answer 3

Won Nobel Prize for characterization of a single ion channel using patch clamp technique

Question 4

Hodgkin & Huxley

Answer 4

• Examined ionic bases of AP (giant squid axon)

* Voltage clamp technique

Question 5

Bliss & Lomo

Answer 5

Discovered LTP at glutamatergic synapses in hippocampal formation

Question 6

Hebb

Answer 6

• Mechanism for synaptic plasticity
• Increase in synaptic efficiency due to presynaptic neuron always activating postsynaptic neuron
• May explain associative learning

Question 7

Kasanetz et al.

Answer 7

Loss of synaptic plasticity in NAc ⇋ inability to control drug intake

Question 8

Dacher & Nugent

Answer 8

• Method: in vivo electrophysiology after low frequency stimulation (LFS)
• LTD occurs on VTA GABA-DA synapses