Important Drug Interactions

Question 1

<p>

| Antimicrobials that cause hemolysis in G6PD-deficiency:</p>

Answer 1

<ul>
	<li>
		Furazolidone</li>
	<li>
		Isoniazid</li>
	<li>
		Nitrofurantoin</li>
	<li>
		Primaquine</li>
	<li>
		Sulfamethoxazole</li>
</ul>

Question 2

<p>

| Therapeutic CSF levels obtained without inflamed meninges:</p>

Answer 2

<ul>
	<li>
		Chloramphenicol</li>
	<li>
		Flucytosine</li>
	<li>
		Isoniazid</li>
	<li>
		<strong>Rifampicin</strong></li>
	<li>
		Sulfamethoxazole</li>
	<li>
		Trimethoprim</li>
</ul>

Question 3

<p>

| Therapeutic CSF concentration obtained <strong>with</strong> inflamed meninges:</p>

Answer 3

<ul>
	<li>
		<strong>Ampicillin</strong></li>
	<li>
		Aztreonam</li>
	<li>
		Carbenicillin</li>
	<li>
		Cefotaxime</li>
	<li>
		Ceftazidime</li>
	<li>
		Cefrtriaxone</li>
	<li>
		Cefuroxime</li>
	<li>
		Ciproflaxin</li>
	<li>
		Cloxacillin</li>
	<li>
		Ethambutol</li>
	<li>
		Imipenem</li>
	<li>
		Mezlocillin</li>
	<li>
		Nafcillin</li>
	<li>
		Penicillin</li>
	<li>
		Piperacillin</li>
	<li>
		Ticarcillin</li>
</ul>

Question 4

<p>

| Antrimicrobials with significant adverse effects on the fetus:</p>

Answer 4

<ul>
	<li>
		Metronidazole</li>
	<li>
		Streptomycin</li>
	<li>
		Tetracycline</li>
</ul>

Question 5

<p>

| Ampicillin effect on nursing babies:</p>

Answer 5

<p>

| Non signficant, but may cause diarrhea and allergic sensitization</p>

Question 6

<p>

| Effect of chloramphenicol on nursing babies:</p>

Answer 6

<p>

| Possibility of bone marrow supression</p>

Question 7

<p>

| Effect of isoniazid on nursing babies:</p>

Answer 7

<p>

| Possibility of pyridoxone deficiency</p>