Important Cytokines Flashcards
1
Q
IL-1
A
=osteoclast-activating factor
- fever
- acute inflammation
- induce chemokine secretion, attract WBC’s
2
Q
IL-6
A
- fever
- stimulates production of acute-phase proteins
3
Q
IL-8
A
-Main chemotactic factor for neutrophils
NEUTROPHILS
4
Q
IL-12
A
- Activates NK cells
- Induces differentiation of T cells into Th1 cells
5
Q
TNF-alpha
A
- WBC recruitment
- Mediates septic shock
- activates endothelium
- Cachexia (cancer)
6
Q
Which cytokine causes Cachexia in malignancy?
A
-TNF-alpha
7
Q
IL-2
A
-Stimulates growth of all T cells and NK cells
8
Q
IL-3
A
- supports growth and differentiation of bone marrow stem cells
- functions like GM-CSF
9
Q
Interferon-gamma
A
- Stimulates macrophages to kill phagocytosed pathogens
- Secreted by NK cells in response to IL-12
- Activates NK cells to kill virus-infected cells
- increase MHC expression and antigen presentation in all cells
10
Q
IL-4
A
- Induces differentiation into Th2 cells
- Enhances class switching to IgE and IgG
- Promotes growth of B cells
11
Q
IL-5
A
- Enhances class switching to IgA
- Stimulates differentiation of B cells
- Stimulates growth and differentiation of eosinophils
12
Q
IL-10
A
- Modulates inflammatory response (secreted by Treg)
- Decreases expression of MHC II and Th1 cytokines
- Inhibits activated macrophages & dendritic cells
13
Q
Which cytokines attenuate the immune response?
A
- TGG-beta
- IL-10
14
Q
Which cytokines are secreted by macrophages?
A
IL-1
IL-6
IL-8
IL-12
TNF-alpha
15
Q
Which cytokines are secreted by all T cells?
A
IL-2
IL-3
