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Term 3: Immunology/Pathology > Important Cytokines > Flashcards

Important Cytokines Flashcards

1
Q

IL-1

A

=osteoclast-activating factor

  • fever
  • acute inflammation
  • induce chemokine secretion, attract WBC’s
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2
Q

IL-6

A
  • fever

- stimulates production of acute-phase proteins

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3
Q

IL-8

A

-Main chemotactic factor for neutrophils

NEUTROPHILS

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4
Q

IL-12

A
  • Activates NK cells

- Induces differentiation of T cells into Th1 cells

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5
Q

TNF-alpha

A
  • WBC recruitment
  • Mediates septic shock
  • activates endothelium
  • Cachexia (cancer)
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6
Q

Which cytokine causes Cachexia in malignancy?

A

-TNF-alpha

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7
Q

IL-2

A

-Stimulates growth of all T cells and NK cells

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8
Q

IL-3

A
  • supports growth and differentiation of bone marrow stem cells
  • functions like GM-CSF
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9
Q

Interferon-gamma

A
  • Stimulates macrophages to kill phagocytosed pathogens
  • Secreted by NK cells in response to IL-12
  • Activates NK cells to kill virus-infected cells
  • increase MHC expression and antigen presentation in all cells
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10
Q

IL-4

A
  • Induces differentiation into Th2 cells
  • Enhances class switching to IgE and IgG
  • Promotes growth of B cells
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11
Q

IL-5

A
  • Enhances class switching to IgA
  • Stimulates differentiation of B cells
  • Stimulates growth and differentiation of eosinophils
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12
Q

IL-10

A
  • Modulates inflammatory response (secreted by Treg)
  • Decreases expression of MHC II and Th1 cytokines
  • Inhibits activated macrophages & dendritic cells
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13
Q

Which cytokines attenuate the immune response?

A
  • TGG-beta

- IL-10

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14
Q

Which cytokines are secreted by macrophages?

A

IL-1

IL-6

IL-8

IL-12

TNF-alpha

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15
Q

Which cytokines are secreted by all T cells?

A

IL-2

IL-3

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16
Q

Which cytokines are secreted from Th1 cells?

A

-Interferon-gamma

17
Q

Which cytokines are secreted from Th2 cells?

A

IL-4

IL-5

IL-10

18
Q

IL-17

A
  • massive recruitment of neutrophils
  • helps against extracellular bacteria and fungi

(produced by (Th17)

19
Q

IL-21

A

Growth factor for Th17 cells

produced by Th17

20
Q

IL-13

A
  • stimulates production of mucus in intestine
  • prevents more pathogens from entering there
  • produced by Th2 cells
21
Q

Which cytokines stimulate Th2 cells?

22
Q

Which cytokines stimulate Th1 cells?

A
  • INF-g

- IL-12

23
Q

Which cytokines inhibit Th1 cells?

A

IL-4

IL-10

24
Q

Which cytokines inhibit Th2 cells?

A

IFN-g (from Th1)

Term 3: Immunology/Pathology (17 decks)

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