Important ADRs

Question 1

Clozapine

Answer 1

AGRANULOCYTOSIS, seizure, myocarditis, metabolic syndrome (check lipids/glucose with CBC)

Question 2

Risperidone

Answer 2

Hyperprolactinemia, gynecomastia, NMS

Question 3

TCAs

Answer 3

Arrhythmias, hypotension, anti-sludge, sexual side effects, weight gain, GI probs

Question 4

SSRIs

Answer 4

HA, weight changes, GI, and sexual side effects

Question 5

SNRIs

Answer 5

HYPERTENSION, blurred vision, sexual side effects, GI

Question 6

Buproprion

Answer 6

Lowers seizure threshold, avoid use in bulimics

Question 7

Trazodone

Answer 7

Priapism

Question 8

Mirtazepine

Answer 8

Weight gain, sedation

Question 9

Lithium

Answer 9

Epstein's anomaly - avoid in preg
Nephrotoxic
Nephrogenic DI
Tremors, weight gain, GI
Severe?: confusion, lethargy, ataxia, abnl reflexes

Question 10

Valproate

Answer 10

Liver problems (fatty), weight gain, alopecia (valopecia), tremors

Toxic levels? Hyponatremia, coma, death.

Question 11

Lamotrigine

Answer 11

Steven-Johnsons

Question 12

ECT

Answer 12

Transient memory loss, HA

Question 13

Ziprazidone

Answer 13

Prolonged QT

Question 14

Cefoxitan/cefotetan

Answer 14

Bleeding (by depleting prothrombin)

Question 15

Ceftriaxone

Answer 15

Inadequate bilirubin metabolism:
AVOID in NEONATES –> Kernicterus
(competes with bili for albumin…and wins)

Question 16

Fluoroquinolones

Answer 16

Bone growth abnormalities in kids

Tendon RUPTURE

Question 17

Bactrim

Answer 17

G6PD - hemolytic anemia
Bone marrow suppression : FOLATE ANTAGONIST
(like MTX, phenytoin or dapsone)

Question 18

Linezolid

Answer 18

Serotonin syndrome- beware

*REVERSIBLE bone marrow toxicity

Question 19

Acyclovir

Answer 19

Renal toxicity : via crystal-nephropathy; obstructive

Question 20

EPO

Answer 20

HTN

Question 21

Fibrates+Statins

Answer 21

Increased myositis risk

Question 22

Cholestyramine

Answer 22

GI complaints, constipation, flatus

Interacts with other meds

Question 23

Niacin

Answer 23

Hyperuricemia, hyperglycemia, pruritis

Question 24

HCTZ

Answer 24

Hyperglycemia, Hyperlipidemia, Hypertriglyceridemia

Question 25

Amlodipine

Answer 25

LE edema

Question 26

Hydroxychloroquine

Answer 26

Retinopathy

Question 27

Pioglitazone

Answer 27

CHF and bladder cancer

Question 28

Doxycycline

Answer 28

Tooth discoloration, Fanconi syndrome (type II), photosensitivity, esophagitis

Question 29

Daptomycin

Answer 29

Elevated CPK

Question 30

Abacavir

Answer 30

HLAB5701- hypersensitivity

Question 31

Prasugrel

Answer 31

Hemorrhagic stroke in elderly (>75)

Question 32

Imipenim

Answer 32

Seizures

Question 33

Pyrazinamide

Answer 33

Hyperuricemia (like HCTZ)