Impaired/Defective Production Anemia Flashcards
Impaired/ defective production anemia
Iron deficiency anemia
Anemia of chronic disease
Sideroblastic anemia
Thalassemia
Lead poisoning
Porphyrias
Megaloblastic Anemia
Aplastic anemia
Myelophthistic anemia (BM Replacement)
Most common form of anemia
IDA
Low serum iron, ferritin, hgb/hct, RBC indices, retics count
IDA
IDA increase in
RDW and TIBC
Inability to use available normal RBC
ACD
ACD is a impaired release of storage iron associated with increased __________ level
Hepcidin
Associated with persistent infection, chronic inflammatory disorder
ACD
ACD increased in
ESR, ferritin
ACD decrease in
Serum iron and TICB
Caused by blocks on the protoporphyrin pathway resulting in defective hemoglobin synthesis and iron overload
Sideroblastic anemia
Seen in sideroblastic anemia
2 rbc population (Dimorphic)
Increased ferritin and serum iron
Sideroblastic anemia
Excess iron accumulates in _____________ in immature erythrocytes (ringed sideroblast)
Mitochondrial region
Decreased TIBC
sideroblastic anemia
Increase in TIBC
iron deficiency anemia
Normal to decrease in TICB
Thalassemia
Inherited blood disorder that causes body to less hemoglobin than normal
Thalassemia
Multiple block of protoporphyrin pathway
Lead poisoning
Normocytic Normochromic anemia with BASOPHILIC STIPPLING
Lead poisoning
Group of inherited disorder by a block in the protoporphyrin pathway
Porphyrias
Hematologic findings are insignificant
Porphyrias
Defective DNA synthesis causes abnormal nuclear maturation
Megaloblastic anemia
RNA is Normal, so Cytoplasm is _______
Not affected
Nucleus matures slower than cytoplasm (asynchronism)
Megaloblastic anemia
Bone marrow failure
Aplastic anemia
Aplastic anemia decrease in
Hgb/hct
Retics
Hypoproliferative Anemia caused by replacement of bone marrow by malignant cell fibrotic tissue
Myelophthistic anemia
