Erythrocyte Disorders Flashcards
Process of blood production
Hematopoiesis
Intrauterine hematopoiesis
Mesoblastic phase
Hepatic phase
Myeloid/medullary phase
Begins at 19th day of gestation
Mesoblastic phase
Mesoblastic phase hemoglobin
Gower 1
Gower 2
Portland
Primitive nucleated erythroblast (first cell)
Mesoblastic phase
Begins at 6 weeks of gestation
Hepatic phase
Produce during hepatic phase
RBC, granulocytes, monocytes, and megakaryocytes
Alpha and gamma globin (HbF)
Begins at 5th month of gestation
Medullary phase
Myeloid - erythroid ratio
3:1 (4:1)
Bone marrow producing mainly granulocytes
Medullary/myeloid phase
At when gamma-beta globin switch
6th month
Percentage of newborn active bone marrow
80-90%
60% of BM are active
Young adult (age 20)
Proximal ends of large flat bones, pelvis and sternum
Young age (20)
40% of BM are active and 60% is fat
Older adult (55)
Ratio of marrow cells to fat (red/yellow BM)
Cellularity
Normocellular
30-70% hematopoietic cells
Hypercellular/hyperplastic
> 70% hematopoietic cells
Hypocellular/hypoplastic
<30% hematopoietic cells
Marrow had few or no hematopoietic cells
Aplastic
Ratio of granulocytes to nucleated erythroid precursor
M:E ratio
Excluded from M:E ratio
Lymphocyte
Monocyte
Pluripotential stem cell
Hematopoiesis
Committed progenitor cells
(Lymphoid or myeloid)
Hematopoiesis
What are the committed progenitor cells
CGU-MEG
CFU-GM (CFU-M)
CFU- GM (CFU-G)
BFU-E (CFU-E)
CFU-Eo
CFU-Bs
Mature cell under thrombopoietin, GM -CSF
Thrombocyte
Mature cell under CFU-M
Monocyte
CFU-G mature cell
Neutrophil
BFU-E mature cells
Erythrocyte
IL-3, IL-4 mature cell
Basophil
Growth factors of monocyte
GM-CSF, M-CSF, IL-3
GM-CSF, G-CSF, IL-3
Neutrophil
Erythrocyte growth factor
Erythropoietin, GM-CSF, IL-3
Eosinophil interleukins
GM-CSF, IL-3, IL-5
IL-3, IL-4
Basophil
