Anemia Due To Accelerated Destruction Of RBC Flashcards
Hemolytic anemia is due to
Intrinsic hemolytic anemia
Extrinsic hemolytic anemia
Defect of red cell itself; hereditary and group as membrane, metabolic or hemoglobin
Intrinsic hemolytic anemia
Factor outside the red cell and acting upon it; always acquired
Extrinsic hemolytic anemia
Intrinsic: Membrane disorder
Hereditary spherocytosis
Paroxysmal nocturnal hemoglobinuria
Hereditary elliptocytosis/ ovalocytosis
Hereditary pyropoikilocytosis
Hereditary stomatocytosis
Hereditary acanthocytosis
Rh null disease
High phosphatidylcholine hemolytic anemia
Hereditary spherocytosis known as
Congenital hemolytic jaundice/anemia
Inherited as non-sex linked dominant trait
Hereditary spherocytosis
Most common in North europeans
Hereditary spherocytosis
Spherocytes die _____
Prematurely
Splenomegaly
Hereditary spherocytosis
Blood films shows microspherocyte
Hereditary spherocytosis
PHN or known as
Machiafava Micheli Syndrome
Chronic intravascular hemolysis
PNH
Acidosis
PNH
Hemoglobinuria occurs during sleep or after awakening
PNH
pH plasma is low
PNH
Severe hemolytic anemia in infants
Hereditary elliptocytosis
Defects involved in hereditary elliptocytosis
Spectrin dimers, unconnected dimer
Moderately severe congenital hemolytic anemia; recessive autosomal trait
Hereditary pyropoikilocytosis
This occurs in blacks
Hereditary pyropoikilocytosis
Hereditary stomatocytosis known as
Hydrocytosis
Rare congenital anemia
Hereditary stomatocytosis
Hydrocytosis is recessive autosomal trait caused by __________ due to increased permeability of membrane
Decreased K
Increase Na
Hydrocytosis 10-30% red cells appear
Mouth like
Inherited due to gene suppression or presence of silent Rh gene (Xo)
Rh null disease
Membrane abnormalities due to absence of all _________ antigens on the red cells
Rh-Hr
Represent an imbalance in the membrane phospholipid in the red cell
High phosphatidylcholine hemolytic anemia
Anemia may increase due to infection or under condition of _____
Stress
