Anemia Due To Accelerated Destruction Of RBC

Question 1

Hemolytic anemia is due to

Answer 1

Intrinsic hemolytic anemia
Extrinsic hemolytic anemia

Question 2

Defect of red cell itself; hereditary and group as membrane, metabolic or hemoglobin

Answer 2

Intrinsic hemolytic anemia

Question 3

Factor outside the red cell and acting upon it; always acquired

Answer 3

Extrinsic hemolytic anemia

Question 4

Intrinsic: Membrane disorder

Answer 4

Hereditary spherocytosis
Paroxysmal nocturnal hemoglobinuria
Hereditary elliptocytosis/ ovalocytosis
Hereditary pyropoikilocytosis
Hereditary stomatocytosis
Hereditary acanthocytosis
Rh null disease
High phosphatidylcholine hemolytic anemia

Question 5

Hereditary spherocytosis known as

Answer 5

Congenital hemolytic jaundice/anemia

Question 6

Inherited as non-sex linked dominant trait

Answer 6

Hereditary spherocytosis

Question 7

Most common in North europeans

Answer 7

Hereditary spherocytosis

Question 8

Spherocytes die _____

Answer 8

Prematurely

Question 9

Splenomegaly

Answer 9

Hereditary spherocytosis

Question 10

Blood films shows microspherocyte

Answer 10

Hereditary spherocytosis

Question 11

PHN or known as

Answer 11

Machiafava Micheli Syndrome

Question 12

Chronic intravascular hemolysis

Answer 12

PNH

Question 13

Acidosis

Answer 13

PNH

Question 14

Hemoglobinuria occurs during sleep or after awakening

Answer 14

PNH

Question 15

pH plasma is low

Answer 15

PNH

Question 16

Severe hemolytic anemia in infants

Answer 16

Hereditary elliptocytosis

Question 17

Defects involved in hereditary elliptocytosis

Answer 17

Spectrin dimers, unconnected dimer

Question 18

Moderately severe congenital hemolytic anemia; recessive autosomal trait

Answer 18

Hereditary pyropoikilocytosis

Question 19

This occurs in blacks

Answer 19

Hereditary pyropoikilocytosis

Question 20

Hereditary stomatocytosis known as

Answer 20

Hydrocytosis

Question 21

Rare congenital anemia

Answer 21

Hereditary stomatocytosis

Question 22

Hydrocytosis is recessive autosomal trait caused by __________ due to increased permeability of membrane

Answer 22

Decreased K
Increase Na

Question 23

Hydrocytosis 10-30% red cells appear

Answer 23

Mouth like

Question 24

Inherited due to gene suppression or presence of silent Rh gene (Xo)

Answer 24

Rh null disease

Question 25

Membrane abnormalities due to absence of all _________ antigens on the red cells

Answer 25

Rh-Hr

Question 26

Represent an imbalance in the membrane phospholipid in the red cell

Answer 26

High phosphatidylcholine hemolytic anemia

Question 27

Anemia may increase due to infection or under condition of _____

Answer 27

Stress