Immunosuppressive drugs

Question 1

Corticosteroids

Answer 1

Name: Prednisone
Used: prophylactic to prevent rejection
Dose: 0.5-2mg/kg. Acute 500-1500 mg per day
Side effects: Glucose intolerance, infections, hypotension
Mode: Oral/ Intravenous

Question 2

Immunosuppressive drugs (7)

Answer 2

1. ) Corticosteroid
2. ) Cyclosporin
3. ) FK-506
4. ) Rapamycin
5. ) Azathioprine
6. ) Methotrexate
7. ) Cyclophosphamide

Question 3

Cyclosporin

Answer 3

Name: Sandimmune

Used: With or without prednisone in renal, hepatic, pancreatic, cardiac transplant

Mode: Inhibits T-helper activation and production of IL-2
Pharm: Absorbed in GI tract, Half life 10-15h
Dose: 15mg/kg before transplant, 3-10mg/kg after
Side effects: Nephro
Mode: Oral