Alzheimers

Question 1

Risk Factors for AD

Answer 1

1. ) Age
2. ) Family history
3. ) Down syndrome

Question 2

Which gene is responsible for majority for AD?

Answer 2

presenilin 1 50%

Question 3

What is the strongest risk factor for LOAD?

Answer 3

Apolipoprotein E

- This is a lipid binding protein that transports lipids to cells to support cholesterol metabolism

Question 4

Which deposits are associated with AD?

Answer 4

Amyloid deposits

Question 5

What disappears in a brain with AD?

Answer 5

1. ) Hippocampus dissappers

2. ) Ventricle decrease

Question 6

How do most cases of AD develop?

Answer 6

They are sporadic with a late onset

Question 7

What is ADAD? How is it characterized?

Answer 7

Autosomal dominant AD.

It has very early onset and rapid progression

Question 8

Typical clinical syndromes of AD?

Answer 8

1. ) Memory defect
2. ) Language disorder
3. ) Can’t recognize environment
4. ) Deficits in executive function
5. ) Unaware of memory compromise
6. ) Cognitive deficits progressively worsen

Question 9

Which 3 drugs are Cholinesterase inhibitors?

Answer 9

1. ) Donepezil
2. ) Rivastigmine
3. ) Galantamine

Question 10

Mementine is an antagonist for which receptor?

Answer 10

NMDA

Question 11

Which drugs targets amyloid plauqes and prevents them from being made?

Answer 11

Aducanumab

Question 12

What does Axona do?

Answer 12

Increases brain metabolism