Depression Flashcards
What is the limbic system responsible for?
Emotions
What are the 3 monoamines?
- ) NE
- ) Serotonin (5HT)
- ) Dopamine
2 ways that neuron terminates monoamine signal?
- ) Monoamine oxidase- breaks them down
2. ) Monamine reuptake
How did the first antidepressant work?
By blocking monamine breakdown and reuptake
How do AD ACTUALLY work?
They overstimulate the nerves with monamines which then cause
- ) Downregulation/ decrease in nerve number
- ) Overstim/ anxiety
Does downregulation help depression?
Yes
How does stress effect the size of the hippocampus?
Increased stress = increased cortisol= decreased size of hippocampus
how does Serotonin effect the hippocampus?
It increases the production of new cells to replaces the ones destroyed by cortisol
SSRI side effects
- ) Decreased sex drive
- ) Worsen of suicidal thoughts
- ) More side effects if stopped abruptly
When are TCA (Tryplines) used?
Only if newer drugs don’t work
How do Monamine Oxidase Inhbitors work? MAOI
Blocks the enzyme that metabolize monoamines so that they stay in the synapse longer
Name 2 MAOI
- ) Tranycypromine
2. ) Phenelzine
What foods should be avoided with MAOI?
Cheese, fruits, wines, pickles
Foods containing Tyramine
What is Emsam (Seligine)?
MAOI slow release patch.
Do not need diet restriction with this
What drug acts as an SSRI at a low dose?
Effexor
