immunosuppressive agents Flashcards
main autoimmune diseases
rheumatoid arthritis psorasis graves disease addisons crohns disease multiple sclerosis
macrophages induce ______
CD4 T cells
CD4 T cells can divide into _____ and _____
cytotoxic B cells (by IL-2)
antigen specific B cells by (IL-4/5)
main target of immunosuppresive agents
CD4 cells
an example of a antigen presenting cell
macrophage
immunosuppresive agents can attack CD4 cells at 3 different places
initial stimulation
activation
replication
2 things all immunosuppresives increase
chance of infection
malignancy
polyclonal antibodies
mixture of many different antibodies we all have
where is antithymocyte globulin from
made in horse/rabbit. may cause allergic response
all monoclonal antibodies end in what
mab
all monoclonal antibodies are given how
injection
middle of word tells us about what
target
li =
tu =
li = immune cell target tu = tumor
middle end of word tells us what
source
xi =
zu =
u =
xi= chimeric source- mouse antibody with some human zu= humanized- human Ab with some mouse u = fully human
which is most antigenic
xi
progressive multifocal leukoencephalopathy is what
fatal viral disease of CNS
cyclosporine mechanism chain
- binds intracellular to a protein called cyclophyllin
- complex inhibits enzyme called calcineurophosphatase
- this prevents activation of NFAT
- this prevents activation of genes that code for IL-2 IL-3, TNF alpha
- end result is T cell is not activated.
which is more efficacious cyclosporine or tacrolimus
tacrolimus
long term use of these results in
glucocorticoids
blockers of internal T cell processes that are used for trnasplantation
cyclosporine
tacrolimus
sirolimus
blockers of internal T cell processes that are used for psorasis
everolimus
ending with Ib means what
kinase inhibitors
janus kinase inhibitors are also called what
JAK-STAT
are inhibitors of T cell replication specific or non specific
non specific
this is a more specific replacement for azathioprine
mycophenolate mofetil
inhibition of inosine monophosphate dehydrogenase causes what
inhibition of guanosine synthesis
DOC for early treatment of RA
methotrexate
this drug is an analog of folic acid
methotrexate
methotrexate is called a
disease modifying anti rheumatic drug (DMARD)
methotrexate works on any cell that has _____ turnover
rapid
