immunosuppressive agents

Question 1

main autoimmune diseases

Answer 1

rheumatoid arthritis 
psorasis 
graves disease
addisons
crohns disease
multiple sclerosis

Question 2

macrophages induce ______

Answer 2

CD4 T cells

Question 3

CD4 T cells can divide into _____ and _____

Answer 3

cytotoxic B cells (by IL-2)

antigen specific B cells by (IL-4/5)

Question 4

main target of immunosuppresive agents

Answer 4

CD4 cells

Question 5

an example of a antigen presenting cell

Answer 5

macrophage

Question 6

immunosuppresive agents can attack CD4 cells at 3 different places

Answer 6

initial stimulation
activation
replication

Question 7

2 things all immunosuppresives increase

Answer 7

chance of infection

malignancy

Question 8

polyclonal antibodies

Answer 8

mixture of many different antibodies we all have

Question 9

where is antithymocyte globulin from

Answer 9

made in horse/rabbit. may cause allergic response

Question 10

all monoclonal antibodies end in what

Answer 10

mab

Question 11

all monoclonal antibodies are given how

Answer 11

injection

Question 12

middle of word tells us about what

Answer 12

target

Question 13

li =

tu =

Answer 13

li = immune cell target
tu = tumor

Question 14

middle end of word tells us what

Answer 14

source

Question 15

xi =
zu =
u =

Answer 15

xi= chimeric source- mouse antibody with some human
zu= humanized- human Ab with some mouse
u = fully human

Question 16

which is most antigenic

Answer 16

xi

Question 17

progressive multifocal leukoencephalopathy is what

Answer 17

fatal viral disease of CNS

Question 18

cyclosporine mechanism chain

Answer 18

1. binds intracellular to a protein called cyclophyllin
2. complex inhibits enzyme called calcineurophosphatase
3. this prevents activation of NFAT
4. this prevents activation of genes that code for IL-2 IL-3, TNF alpha
5. end result is T cell is not activated.

Question 19

which is more efficacious cyclosporine or tacrolimus

Answer 19

tacrolimus

Question 20

long term use of these results in

Answer 20

glucocorticoids

Question 21

blockers of internal T cell processes that are used for trnasplantation

Answer 21

cyclosporine
tacrolimus
sirolimus

Question 22

blockers of internal T cell processes that are used for psorasis

Answer 22

everolimus

Question 23

ending with Ib means what

Answer 23

kinase inhibitors

Question 24

janus kinase inhibitors are also called what

Answer 24

JAK-STAT

Question 25

are inhibitors of T cell replication specific or non specific

Answer 25

non specific

Question 26

this is a more specific replacement for azathioprine

Answer 26

mycophenolate mofetil

Question 27

inhibition of inosine monophosphate dehydrogenase causes what

Answer 27

inhibition of guanosine synthesis

Question 28

DOC for early treatment of RA

Answer 28

methotrexate

Question 29

this drug is an analog of folic acid

Answer 29

methotrexate

Question 30

methotrexate is called a

Answer 30

disease modifying anti rheumatic drug (DMARD)

Question 31

methotrexate works on any cell that has _____ turnover

Answer 31

rapid