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Pharm test 4 > Aspirin and NSAID's > Flashcards

Aspirin and NSAID's Flashcards

1
Q

general physio effects of NSAIDs

A

analgesic, antipyretic, antiinflammatory, antiplatelet

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2
Q

low does use of NSAID’s

A

achs and pains, inhibition of clotting

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3
Q

high dose of NSAID’s used for what

A

arthritis

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4
Q

prototype NSAID

A

aspirin

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5
Q

aspirin made by what two parts

A

salicylic acid and acetyl groups called ASA

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6
Q

T/F ASA is a weak acid

A

True

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7
Q

what happens to ASA in plasma

A

dissociates to salicylic acid which binds strongly to plasma proteins

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8
Q

aspirin MOA

A

inhibits cyclooxygenase which which is needed in metabolism of prostaglandin (PG)

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9
Q

what is an antipyretic effect?

A

lowers temperature in fever

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10
Q

how is aspirin an antipyretic?

A

cause vasodilation in peripherals to which increases heat radiation

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11
Q

increase in prostaglandins causes what in hypothalamus?

A

increase in body temp

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12
Q

aspirins analgesic effect is due to what?

A

due to decrease in prostaglandin production. (PG’s are neuromodulators)

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13
Q

how is aspirin an anticlotic effect

A

COX prevents synthesis of TXA2, inhibiting platelet

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14
Q

T/F ASA may decrease signs of inflammation but also may decrease immune cell migration and activity.

A

True

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15
Q

death due to aspirin overdose is caused by what

A

pulmonary edema

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16
Q

most common side effect in toxic dose of aspirin

A

GI irritation- decrease PG production by intestinal mucosa, decrease mucous production in GI tract, decrease bicarbonate

17
Q

lethal dose in children is how much?

A

4 grams or 12 tablets

18
Q

is acetaminophen a NSAID?

A

no

19
Q

acetaminophen is a good ____ ____ _____

A

non-narcotic analgesic

20
Q

what effects do acetaminophen lack that aspirin has?

A

acetaminophen has no antiinflammaotry effects

and no antiplatelet effects

21
Q

T/F/ acetaminophen has more GI side effects

A

false

22
Q

overdose (20-30) tablets can cause what

A

irreversible liver damage

23
Q

irreversible liver damage caused by what?

A

decrease GSH (glutathione) in liver

24
Q

how do you treat decrease of GSH in liver?

A

reducing agent n-acetyl cystine

25
Q

the NSAID’s are derived from what

A

proprionic acid and acetic acid

26
Q

propionic acid derivatives

A

the “pro”s

27
Q

what is ductus arteriosus?

A

opening in aorta/pulmonary artery in newborns because prostaglandin increase holds it open

28
Q

what is given to fix ductur arteriosus

A

indomethacin

29
Q

why does celecoxib cause increase in heart attack and stroke

A

due to greater effect of the drug on production of PGI2 (vasodilator) than on production of TXA (vasoconstriction)

Pharm test 4 (5 decks)

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