Aspirin and NSAID's Flashcards
general physio effects of NSAIDs
analgesic, antipyretic, antiinflammatory, antiplatelet
low does use of NSAID’s
achs and pains, inhibition of clotting
high dose of NSAID’s used for what
arthritis
prototype NSAID
aspirin
aspirin made by what two parts
salicylic acid and acetyl groups called ASA
T/F ASA is a weak acid
True
what happens to ASA in plasma
dissociates to salicylic acid which binds strongly to plasma proteins
aspirin MOA
inhibits cyclooxygenase which which is needed in metabolism of prostaglandin (PG)
what is an antipyretic effect?
lowers temperature in fever
how is aspirin an antipyretic?
cause vasodilation in peripherals to which increases heat radiation
increase in prostaglandins causes what in hypothalamus?
increase in body temp
aspirins analgesic effect is due to what?
due to decrease in prostaglandin production. (PG’s are neuromodulators)
how is aspirin an anticlotic effect
COX prevents synthesis of TXA2, inhibiting platelet
T/F ASA may decrease signs of inflammation but also may decrease immune cell migration and activity.
True
death due to aspirin overdose is caused by what
pulmonary edema
most common side effect in toxic dose of aspirin
GI irritation- decrease PG production by intestinal mucosa, decrease mucous production in GI tract, decrease bicarbonate
lethal dose in children is how much?
4 grams or 12 tablets
is acetaminophen a NSAID?
no
acetaminophen is a good ____ ____ _____
non-narcotic analgesic
what effects do acetaminophen lack that aspirin has?
acetaminophen has no antiinflammaotry effects
and no antiplatelet effects
T/F/ acetaminophen has more GI side effects
false
overdose (20-30) tablets can cause what
irreversible liver damage
irreversible liver damage caused by what?
decrease GSH (glutathione) in liver
how do you treat decrease of GSH in liver?
reducing agent n-acetyl cystine
the NSAID’s are derived from what
proprionic acid and acetic acid
propionic acid derivatives
the “pro”s
what is ductus arteriosus?
opening in aorta/pulmonary artery in newborns because prostaglandin increase holds it open
what is given to fix ductur arteriosus
indomethacin
why does celecoxib cause increase in heart attack and stroke
due to greater effect of the drug on production of PGI2 (vasodilator) than on production of TXA (vasoconstriction)
