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Pharm test 4 > chemo > Flashcards

chemo Flashcards

1
Q

neoplasia

A

uncontrolled replication of human cells

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2
Q

invasivness

A

movement of neoplastic cells to adjacent tissue

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3
Q

metastasis

A

movement of neoplastic cells to distant tissue

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4
Q

nonspecific agents act on what kinds of cells

A

replicating and resting cells

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5
Q

cell specific agents act on what

A

rapidly replicating cells

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6
Q

all non specific agents work how

A

bind to DNA somehow

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7
Q

kinase inhibitors end in what

A

“nib”

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8
Q

alkyl agents work how?

A

add akyl group to DNA, causing DNA cross linking which inhibits cell replication.

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9
Q

which is a nitrogen mustard

A

cyclophosphamide

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10
Q

which causes renal damage and ototoxicity

A

cisplatin

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11
Q

which drugs cause heart muscle degeneration

A

doxorubicin

daunorubicin

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12
Q

drugs associated with free radical formation

A

doxorubicin

daunorubicin

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13
Q

drug that causes pulmonary fibrosis

A

bleomycin

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14
Q

all cell specific agents work how?

A

inhibits enzymes

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15
Q

major SE of methotrexate

A

myelosuppression

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16
Q

how to fix myelosuppression

A

give leukovorin

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17
Q

what does leukovorin do

A

a tetrahydrofolic acid analog

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18
Q

what does leukovorin “rescue”

A

normal cells and not malignant cells

19
Q

leukovorin rescue is associated with what drug

A

methotrexate

20
Q

5 flurouracil does what

A

inhibits thymidylate synthase

21
Q

how does cytarabine work?

A

inhibits DNA polymerase

22
Q

vincristine and vinblastine work how

A

binds to microtubules

23
Q

paciltaxel work how

A

forms abnormal microtubules

24
Q

ixabepilone works how?

A

binds to microtubules

25
Q

etoposide works how?

A

inhibits topoisomerase 2

26
Q

topotecan works how?

A

inhibits topoisomerase 1

27
Q

what causes apoptosis

A

eribulin

28
Q

androgen activity blockers used for what

A

treatment of prostate tumors

29
Q

flutamide does what?

A

blocks androgen receptor

30
Q

leuprolide acts on what

A

receptor activator of GnRH, ultimately down regulates synthesis

31
Q

abiraterone acts on whwat

A

inhibits enzyme CYP17, inhibits androgen synthesis

32
Q

tamoxifen works how

A

blocks a receptor

33
Q

side affect of tamoxifen

A

retinal changes, increased cataracts in eye

34
Q

anastrozole mechanism

A

inhibits enzyme aromatase

35
Q

aromatase does what

A

converts testosterone to estrogen

36
Q

drug used to treat leukemias and lymphomas

A

glucocoritoids, prednisone

37
Q

drug used to treat chronic myelogenous leukemia

A

imitinib

38
Q

how do proteasome inhibitors work?

A

build up of excess proteins causes cell death.

39
Q

used to treat multiple myeloma

A

bortezomib

carfilzomib

40
Q

trastuzumab works how

A

binds to HER2 (blocks receptor)

41
Q

bevacizumab works how

A

blocks VEGF receptor

42
Q

what does blocking VEGF do?

A

prevents growth factor from binding inhibiting formation of blood vessels to tumor cells

43
Q

rituximab is used to treat what

A

chronic lymphocytic leukemia and RA

44
Q

which drug class itself can cause neoplasia

A

alkylating agents

Pharm test 4 (5 decks)

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