Glucocorticoids

Question 1

corticoids and steroids are made from this base molecule

Answer 1

cholesterol

Question 2

T/F cortisol is a glucocorticoid

Answer 2

True

Question 3

cortisol is derived from what

Answer 3

17-OH cortisol which is derived from 17-OH Progesterone

Question 4

binding of steroids to intracellular DNA causes what

Answer 4

transactivation or transrepression

Question 5

first commercial glucocorticoid available

Answer 5

hydrocortizone

Question 6

glucocorticoids induce what

Answer 6

lipocortin 1

Question 7

lipocortin 1 does what

Answer 7

inhibit phospholipase A2 arachidonic acid

and also inhibits cytokines

Question 8

inhibition of phospholipase A2 arachiodonic acid does what?

Answer 8

inhibits synthesis of prostaglandins and leukotrienes

Question 9

other general characteristics of glucocorticoids

Answer 9

high lipid soluble
orally, topically, inhalation
absorbed readily everywhere

Question 10

main effect of glucocorticoids

Answer 10

suppress immune system

Question 11

T/F glucocorticoids can cause mineralcorticoid activity as well

Answer 11

True

Question 12

T/F you want to limit the mineralcorticoid activity

Answer 12

True

Question 13

can prodrugs be used topically?

Answer 13

no, must be metabolized by P450

Question 14

whether topically used drugs get absorbed systemically depends on what

Answer 14

dose, duration, potency, size of area covered, occlusive dressing, skin damage, thickness of skin

Question 15

benefits of ointment

Answer 15

increase absorption. occlusive. long duration

Question 16

T/F people who get adrenal suppression done to them for cushings have to take glucocorticoids for life

Answer 16

True