Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

UWorld > immunosuppressants/anti-neoplastic agents > Flashcards

immunosuppressants/anti-neoplastic agents Flashcards

1
Q

methotrexate

A

MOA: folic acid analog, inhibits dihydrofolate reductase
USE: cancer, RA, IBD, psoriasis, abortion
ADR: myelosuppression (leucovorin), teratogen, macrovesicular fatty change in liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

5-FU

A

MOA: pyrimidine analog that binds folic acid, inhibits thymidylate synthase
USE: cancer
ADR: myelosuppression (leucovorin), photosensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

cytarabine

A

MOA: pyrimidine analog, inhibits DNA polymerase
USE: leukemia, lymphoma
ADR: panCYTopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

6-MP, azathioprine

A

MOA: purine analogs, activated by HGPRT
USE: RA, SLE, preventing organ rejection, IBD, leukemia
ADR: myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

dactinomycin

A

MOA: intercalates in DNA
USE: childhood tumors
ADR: myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

doxorubicin

A

MOA: generates free radicals, intercalates in DNA and breaks it
USE: cancer
ADR: dilated cardiomyopathy (use dexrazoxane to prevent), myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

bleomycin

A

MOA: free radicals break DNA strains
USE: cancer
ADR: pulmonary fibrosis, skin changes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

cyclophosphamide

A

MOA: alkylating agent
USE: cancer
ADR: myelosuppression, hemorrhagic cystitis (mesna)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

busulfan

A

MOA: cross-links DNA
USE: CML, bone marrow ablation before transplantation
ADR: severe myelosuppression, pulmonary fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

cisplatin, carboplatin

A

MOA: cross-links DNA
USE: cancer
ADR: nephrotoxicity, acoustic nerve damage (prevent with amifostine and chloride diuresis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

etoposide, teniposide

A

MOA: inhibits TOPOisomerase II
USE: cancer
ADR: myelosuppression, alopeica

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

tamoxifen, raloxifene

A

MOA: SERM antagonist in breast, agonist in bone
USE: breast cancer, osteoporosis
ADR: hot flashes, risk of endometrial cancer (only tamoxifen)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

trastuzumab

A

herceptin
MOA: HER-2 antibody
USE: HER-2 breast cancer, gastric cancer
ADR: cardiotoxicity, “HEARTceptin”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

rituximab

A

MOA: CD20 antibody
USE: cancer, RA, ITP
ADR: risk of PML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

vemurafenib

A

MOA: inhibits BRaf kinase
USE: metastatic melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

bevacizumab

A

MOA: VEGF antibody
USE: cancer
ADR: hemorrhage, impaired would healing

17
Q

cyclosporine

A

MOA: calcineurin inhibitor, binds cyclophilin, prevents IL-2, blocks T-cell activation
USE: transplant rejection prophylaxis, psoriasis, RA
ADR: nephrotoxicity, gingival hyperplasia, hirsutism, others

18
Q

tacrolimus

A

MOA: calcineurin inhibitor, binds FKBP
USE: transplant rejection prophylaxis
ADR: nephrotoxicity, risk of DM

19
Q

rapamycin

A

sirolimus
MOA: mTOR inhibitor, binds FKBP, blocks IL-2….
MOA: kidney transplant rejection prophylaxis
ADR: non-nephrotoxic

20
Q

basiliximab

A

MOA: IL-2 antibody
USE: kidney transplant rejection prophylaxis
ADR: edema, HTN, tremor

21
Q

azathioprine

A

MOA: precursor of 6-MP, inhibits lymphocyte proliferation by blocking nucleotide synthesis
USE: transplant rejection, RA, Crohn, other autoimmune

22
Q

glucocorticoids

A

MOA: inhibit NF-kB to suppress B and T cell function by decreasing transcription of cytokines

23
Q

use of IFN-alpha

A

HBV, HCV, kaposi, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma

24
Q

use of IFN-beta

A

MS

25
Q

use of IFN-gamma

A

CGD

26
Q

alemtuzumab

A

MOA: CD52
USE: CLL

27
Q

cetuximab

A

MOA: EGFR

28
Q

infliximab, adalimumab

A

MOA: TNF-alpha antibody
USE: PAIR (HLA-B27)

29
Q

natalizumab

A

MOA: alpha4-integrin
USE: MS, Crohn

30
Q

abciximab

A

MOA: glycoprotein IIb/IIIa antibody
USE: anti-platelet to prevent ischemic complications in percutaneous coronary intervention

31
Q

denosumab

A

MOA: RANKL (inhibits osteoclast maturation)
USE: osteoporosis

32
Q

palivizumab

A

MOA: RSV F protein
USE: RSV prophylaxis for high-risk infants

UWorld (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions