Immunosuppressants Flashcards
Tacrolimus
Calcineurin Inhibitor
Inhibit NFAT, a downstream contributor to IL-2 synthesis
IV or oral - CYP3A metabolism
Nephrotoxicity, Neurotoxicity, Hyperglycemia
First line immunosuppressive
Prednisone & Prednisolone
Organ transplantation
GvHD
Autoimmune disorders
Calcineurin Inhibitors
Fusion protein that recognizes CD2
Plaque psoriasis
Alefacept
Inhibits IMP Dehydrogenase in S Phase and inhibits purine synthesis
Organ Transplantation
SE: Myelosuppression, GI upset
Mycophenolate Mofetil
Inhibit NF-kB
Prednisone & Prednisolone
Etanercept, Adalimumab, Golimumab, Infliximab, Certolizumab
TNF-alpha/beta blockers
Rheumatoid Arthritis
SE: Susceptible to infection, Infusion reaction
TNF-alpha/beta blockers
Etanercept, Adalimumab, Golimumab, Infliximab, Certolizumab
Rheumatoid Arthritis
Inhibits mTOR halting cell at G1-S Checkpoint
Organ Transplantation
SE: Myelosuppression, Hyperlipidemia
Rapamycin (Sirolimus)
Purine analog (6-Thio-IMP)
Azathioprine
Azathioprine
Purine analog (6-Thio-IMP) Organ transplantation, RA, Induction/maintenance of remission of ulcerative colitis SE: Myelosuppression, Hepatic Toxicity
Anti-Proliferative/Anti-metabolic
Rapamycin (Sirolimus) Mycophenolate Mofetil Azathioprine Methotrexate Cyclophosphamide
Calcineurin Inhibitors
Inhibit NFAT, a downstream contributor to IL-2 synthesis
Oral - CYP3A metabolism
Nephrotoxicity
Cyclosporin
SE: Protein catabolism, Central adiposity, Hyperglycemia, Osteoporosis, Adrenal Insufficiency
Prednisone & Prednisolone
Antithymocyte Globulin: (ATG and ALG)
Ab that recognizes a wide variety of antigens on T cells
Acute transplant rejection
SE: Fever, chills, potentially hypotension
Leukopenia, thrombocytopenia, HAMA Reaction