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Pharmacology > Immunosuppressants > Flashcards

Immunosuppressants Flashcards

1
Q

Tacrolimus

A

Calcineurin Inhibitor
Inhibit NFAT, a downstream contributor to IL-2 synthesis
IV or oral - CYP3A metabolism
Nephrotoxicity, Neurotoxicity, Hyperglycemia

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2
Q

First line immunosuppressive

A

Prednisone & Prednisolone

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3
Q

Organ transplantation
GvHD
Autoimmune disorders

A

Calcineurin Inhibitors

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4
Q

Fusion protein that recognizes CD2

Plaque psoriasis

A

Alefacept

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5
Q

Inhibits IMP Dehydrogenase in S Phase and inhibits purine synthesis
Organ Transplantation
SE: Myelosuppression, GI upset

A

Mycophenolate Mofetil

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6
Q

Inhibit NF-kB

A

Prednisone & Prednisolone

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7
Q

Etanercept, Adalimumab, Golimumab, Infliximab, Certolizumab

A

TNF-alpha/beta blockers
Rheumatoid Arthritis
SE: Susceptible to infection, Infusion reaction

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8
Q

TNF-alpha/beta blockers

A

Etanercept, Adalimumab, Golimumab, Infliximab, Certolizumab

Rheumatoid Arthritis

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9
Q

Inhibits mTOR halting cell at G1-S Checkpoint
Organ Transplantation
SE: Myelosuppression, Hyperlipidemia

A

Rapamycin (Sirolimus)

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10
Q

Purine analog (6-Thio-IMP)

A

Azathioprine

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11
Q

Azathioprine

A 
Purine analog (6-Thio-IMP)
Organ transplantation, RA, Induction/maintenance of remission of ulcerative colitis
SE: Myelosuppression, Hepatic Toxicity
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12
Q

Anti-Proliferative/Anti-metabolic

A 
Rapamycin (Sirolimus)
Mycophenolate Mofetil
Azathioprine
Methotrexate
Cyclophosphamide
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13
Q

Calcineurin Inhibitors
Inhibit NFAT, a downstream contributor to IL-2 synthesis
Oral - CYP3A metabolism
Nephrotoxicity

A

Cyclosporin

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14
Q

SE: Protein catabolism, Central adiposity, Hyperglycemia, Osteoporosis, Adrenal Insufficiency

A

Prednisone & Prednisolone

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15
Q

Antithymocyte Globulin: (ATG and ALG)

A

Ab that recognizes a wide variety of antigens on T cells
Acute transplant rejection
SE: Fever, chills, potentially hypotension
Leukopenia, thrombocytopenia, HAMA Reaction

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16
Q

Muromonab-CD3

A

Murine monoclonal antibody directed against the human CD3 molecule
Acute allograft rejection
SE: Cytokine Release syndrome, HAMA

17
Q 
Rapamycin (Sirolimus)
Mycophenolate Mofetil
Azathioprine
Methotrexate
Cyclophosphamide
A

Anti-Proliferative/Anti-metabolic

18
Q

Mycophenolate Mofetil

A

Inhibits IMP Dehydrogenase in S Phase and inhibits purine synthesis
Organ Transplantation
SE: Myelosuppression, GI upset

19
Q

Glucocorticoids

A

Prednisone & Prednisolone

20
Q

Cyclosporin

A

Calcineurin Inhibitor
Inhibit NFAT, a downstream contributor to IL-2 synthesis
Oral - CYP3A metabolism
Nephrotoxicity

21
Q

Rapamycin (Sirolimus)

A

Inhibits mTOR halting cell at G1-S Checkpoint
Organ Transplantation
SE: Myelosuppression, Hyperlipidemia

22
Q

Murine monoclonal antibody directed against the human CD3 molecule
Acute allograft rejection
SE: Cytokine Release syndrome, HAMA

A

Muromonab-CD3

23
Q

Alkylating agent that cross-links a number of cellular macromolecules with DNA

A

Cyclophosphamide

24
Q

Cyclophosphamide

A

Alkylating agent that cross-links a number of cellular macromolecules with DNA
Organ rejection, Autoimmune disorders, Wegener’s Granulomatosus
SE: Suppression of all rapidly growing tissue, Pancytopenia, GI upset

25
Q

Organ transplantation, RA, Induction/maintenance of remission of ulcerative colitis

A

Azathioprine

26
Q

Rho(D) Immune Globulin

A

Binds Rho antigens and prevents maternal immune system from sensitizing to them
Rhesus incompatibility

27
Q

Prednisone & Prednisolone

A

Transactivation - bind to steroid hormone receptors, translocate to the nucleus, and promote synthesis of regulatory peptides
Associated with Adverse Effects

Transrepression - bind to steroid hormone receptors,translocate to the nucleus, and suppress synthesis of NFkB responsive elements

28
Q

Ab that recognizes a wide variety of antigens on T cells

Acute transplant rejection

A

Antithymocyte Globulin: (ATG and ALG)

29
Q

Calcineurin Inhibitor
Inhibit NFAT, a downstream contributor to IL-2 synthesis
IV or oral - CYP3A metabolism
Nephrotoxicity, Neurotoxicity, Hyperglycemia

A

Tacrolimus

30
Q

Alefacept

A

Fusion protein that recognizes CD2

Plaque psoriasis

31
Q

Methotrexate

A

Inhibits DHF Reductase
Remission of IBD, RA, GvHD
SE: Myelosuppression, Hepatic Toxicity

32
Q

Inhibits DHF Reductase
Remission of IBD, RA, GvHD
SE: Myelosuppression, Hepatic Toxicity

A

Methotrexate

Pharmacology (19 decks)

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