Antiretrovirals

Question 1

Maraviroc

Answer 1

CCR5 inhibitor

Question 2

Enfuvirtide

Answer 2

Fusion (gp41) inhibitor

Injection site irritation

Question 3

Raltegravir

Answer 3

Integrase Strand Inhibitor

Metabolized by Glucuronidation
Very few side effects, well-tolerated

Question 4

NRTI’s

Answer 4

Nucleoside Analogs - Chain Terminators
All metabolized by kidney except Abacavir

M184V mutation - will be selected for if you use this as mono therapy. Don’t.

Question 5

Abacavir (ABC)

Answer 5

NRTIs
HLA-B57:01 - Steven’s Johnson Syndrome

Should I re-challenge? NO.
I have no idea why. But NO.

Metabolized by LIVER

Question 6

Didanosine

Answer 6

NRTIs

Pancreatitis, Peripheral neuropathy

Question 7

Stavudine

Answer 7

NRTIs - Thymidine Analog

Pancreatitis, Peripheral neuropathy

Question 8

Lamivudine

Answer 8

NRTIs

No SE listed

Question 9

Tenofovir

Answer 9

NRTIs

AKI (Fanconi), Bone Density loss

Question 10

Zidovudine (AZT)

Answer 10

NRTIs - Thymidine Analog

Bone marrow suppression, Mitochondrial Toxicity

M184V mutation - will be selected for if you use this as mono therapy. Don’t.

Question 11

Zalcitabine

Answer 11

NRTIs

Aphthous Ulcerations

Question 12

Delaviridine

Answer 12

NNRTI - bind to a pocket in RT’s
Liver metabolism

K103N mutation

Question 13

Efavirenz

Answer 13

NNRTI- bind to a pocket in RT’s
Liver metabolism

K103N mutation

Question 14

Etravirine

Answer 14

NNRTI- bind to a pocket in RT’s
Liver metabolism

K103N mutation

Question 15

Elvitegravir

Answer 15

Integrase Strand Inhibitor

Metabolized by Glucuronidation
Very few side effects, well-tolerated

Question 16

Dolutegravir

Answer 16

Integrase Strand Inhibitor

Metabolized by Glucuronidation
Very few side effects, well-tolerated

Question 17

Protease Inhibitors

Answer 17

Metabolized by liver, inhibit isoenzyme 3A4
End in -navir

GI side effects

I84V mutation

Question 18

Atazanavir

Answer 18

Protease inhibitor

I84V mutation

Question 19

Darunavir

Answer 19

Protease inhibitor

I84V mutation

Question 20

Indinavir

Answer 20

Protease inhibitor

I84V mutation

Question 21

Cobicistat

Answer 21

CYP450 inhibitor
Like Ritonavir
Often combined with Elvitegravier

Question 22

When to start therapy?

Answer 22

NOW. As soon as someone has a diagnosis. NEVER STOP THERAPY.

Question 23

Post Exposure Prophylaxis

Answer 23

Within 72 hours for 28 days

Reduces risk by 80%

Question 24

M184V

Answer 24

NRTI mutation

Question 25

K103N

Answer 25

NNRTI mutation

Question 26

Ritonavir

Answer 26

Inhibits CYP450, boosting the action of protease inhibitors

Question 27

Preferred Therapy Regimens

Answer 27

R/PI + 2 NRTI’s

INSTI + 2 NRTI’s