Immunology Lecture 13.

Question 1

What are the signals for an NK cell?

Answer 1

IFN-2, IFN-B, TNF-2, IL12

Question 2

Where are NK cells made?

Answer 2

bone marrow

Question 3

What is the default response of an NK cell?

Answer 3

leave the cell alone - activating signals must overcome a threshold

Question 4

Where are NK cells activated?

Answer 4

locally, as opposed to T cells which are activated in lymph tissue

Question 5

What are the unique markers for NK cells?

Answer 5

TLR 3 and TLR 8

Question 6

What molecule helps NK cell recognize self? Is it inhibitory or activating?

Answer 6

CD94:NKG2A complex —> inhibitory

Question 7

What does CD94:NKG2A complex recognize?

Answer 7

MHC Class I (HLA-E) - no peptide needed

Question 8

IL-8

Answer 8

recruit neutrophils

Question 9

What two signals activate NK cells?

Answer 9

2B4-CD48 and NKG2D-MIC

Question 10

CD48

Answer 10

recognizes NK cells (on target cells)

Question 11

CD16

Answer 11

special because it recognizes antibody - only one signal needed to activate the NK cell

Question 12

Where is the threshold set for activating and NK cell?

Answer 12

bone marrow

Question 13

CD94 with what is an activating signal?

Answer 13

NKG2L (as opposed to NKG2A which is an inhibitory signal)

Question 14

How do gamma delta T cells differ from alpha betta T cells?

Answer 14

YD T cells mostly in gut and are abundant in tissues while AB are in blood

Question 15

What do YD T cells recognize?

Answer 15

IPP

Question 16

What is the main function of YD T cells?

Answer 16

promote inflammation

Question 17

Where are MAIT cells?

Answer 17

mucosa