Immunology and dermatology

Question 1

Treatment for a flare of hereditary angioedema

Answer 1

Icatibant (Bradykinin B2 receptor antagnoist) / C1 esterase inhibitor / Fresh frozen plasma

Question 2

Most common cause of angio-oedema

Answer 2

Acute allergic

Question 3

Drugs with the highest risk of drug induced lupus

Answer 3

Procainamide and hydralazine

Question 4

Most common drugs causing anaphylaxis

1. 2.

Answer 4

Penicillins

NSAIDS

Question 5

High risk fruits in people with latex allergy

Answer 5

Banana
Avocado
Chestnut
Kiwi fruit

Question 6

1st line treatment in urticaria

Answer 6

2nd gen antihistamine

Examples of second-generation antihistamines include cetirizine, loratadine, fexofenadine, desloratadine and levocetirizine.

Question 7

Hereditary angioedema is caused by?

Answer 7

A deficiency of C1 esterase inhibitor

Question 8

Hereditary angioedema long term prophylaxis

Answer 8

Long-term prophylaxis can be achieved with androgenic steroids such as stanozolol or antifibrinolytic drugs such as tranexamic acid.

Question 9

Antivirals in adults with chickenpox (indication)

Answer 9

Antiviral treatment is generally recommended in immunocompromised patients and those at special risk (e.g. because of severe cardiovascular or respiratory disease or chronic skin disorder); in such cases, an antiviral is given for ten days with at least seven days of parenteral treatment.

Question 10

Causes of Pityriasis versicolor

Answer 10

Malassezia furfur and Malassezia globosa

Question 11

Stevens-Johnson syndrome vs toxic epidermal necrolysis

Answer 11

are considered to be a single mucocutaneous disease with increasing severity. They can be differentiated by the degree of epidermal detachment seen.

SJS - 10%

TEN - 30%

Question 12

Erythema ab igne

Answer 12

hot water bottle rash

Question 13

Phemigus (vulgaris) vs Bullous pemphigoid

Answer 13

Pemphigus is characterized by shallow ulcers or fragile blisters that break open quickly. Pemphigoid presents with stronger or “tense” blisters that don’t open easily.

Question 14

Exclusion period for impetigo

Answer 14

48hrs after starting abx

Question 15

Erythema chronicum migrans

Answer 15

Target lesion of Lyme disease

Question 16

Erysipelas usual causative organism

Answer 16

Erysipelas is an infection of the superficial epidermis, most frequently caused by Streptococcus pyogenes.

Question 17

Chicken pox incubation period

Answer 17

14-21 days

Question 18

Exfoliative erythroderma

Answer 18

Erythroderma is a term used to describe erythema affecting more than 90% of the body surface. The term exfoliative erythroderma is also used and describes the exfoliation that is found in the condition. It is sometimes also referred to as the ‘red man syndrome’.

Question 19

Most common underlying precipitant for erythroderma

Answer 19

Atopic dermatitis

Question 20

Dermatological manifestation of addisons disease

Answer 20

pigmentation, vitiligo

Question 21

Dermatological manifestation of Cushing’s disease:

Answer 21

pigmentation, striae, hirsutism, acne

Question 22

Dermatological manifestations of Diabetes mellitus:

Answer 22

necrobiosis lipoidica (shiny, yellowish plaques on the shin), xanthoma, granuloma annulare (palpable ring lesions on hands, face or feet)

Question 23

Dermatological manifestations of Crohn’s disease:

Answer 23

erythema nodosum

Question 24

Dermatological manifestations of Ulcerative colitis:

Answer 24

pyoderma gangrenosum, erythema nodosum