Immunology and Allergy

Question 1

Region comprises several genes implicated with allergic disease pathogenesis

Answer 1

5Q23-25

Question 2

DOC for Persistent Mod-Severe AR

Answer 2

Intranasal CS

Question 3

Block of development from pre B cell to B cell

Answer 3

Bruton Disease

Question 4

Bruton Disease Ig

Answer 4

< 250

Question 5

Oral thrush, Depressed Igs

Answer 5

SCID

Question 6

Aberrant Thymus, Susceptible to infection

Answer 6

DiGeorge Syndrome

Question 7

CATCH 22

Answer 7

Cardiac Defect
Abnormal Facies
Thymic aplasia
Cleft Palate
Hypocalcemia
22q11.2

Question 8

Asthmatic mother, eczematous rash in extensors (very young), flexors (older kids)

Answer 8

Atopic dermatitis

Question 9

Immunodeficiency with Thromocytopenia and Eczema

Answer 9

Wiskott - Aldrich Syndrome

Question 10

Tx for Wiskott Aldrich

Answer 10

BM/ Cord Blood Transplantation

Question 11

Gene for Wiskot Aldrich

Answer 11

WASP

Question 12

Gold Standard for Diagnosis of food allergy

Answer 12

Double Blind Placebo controlled Food challenge

Question 13

No production of B Cells

Answer 13

Bruton’s

Question 14

Low IgG with Normal B cells, Inc risk of granuloma

Answer 14

CVID

Question 15

Low or absent IgA

Answer 15

Selective IgA deficiency

Question 16

Dec IgG, IgA, IgE, N/Inc IgM

Answer 16

Hyper IgM syndrome

Question 17

Lack of anti EBNA, Long lived T Cell immunity

Answer 17

Duncan disease

Question 18

Fatal infectious mononucleosis

Answer 18

Duncan Disease

Question 19

Giardiasis

Answer 19

Selective IgA def

Question 20

P. jiroveci pneumonia

Answer 20

Hyper IgM

Question 21

Treatment for B Cell defects

Answer 21

IVIG 400 mg/month

Question 22

Low T Cells, CATCH 22

Answer 22

DeGeorge

Question 23

Treatment for T Cell immunodeficiency

Answer 23

Thymic transplant

Question 24

Absence of B and T Cells, Opportunistic Inf

Answer 24

SCID

Question 25

T cell def, Thromobcytopenia

Answer 25

Wiskott Aldrich

Question 26

Coarse Facies, Pathologic fractures, Aspergillus

Answer 26

Hyper IgE (AD)/ Job Syndrome

Question 27

Higher incidence of Lymphoma

Answer 27

Hyper IgE (AR)

Question 28

Disordered coalescence of Lyosomal Granules

Answer 28

Chediak Higashi

Question 29

Oculocutaneous albinism, Light skin and silvery hair, Rotary Nystagmus

Answer 29

Chediak Higashi

Question 30

Impaired neutrophil adhesion and activation, decreased binding to C3Bi, Bac infection with lack of pus formation

Answer 30

Leukocyte adhesion deficiency

Question 31

Defect in generation of microbicidal oxygen metabolites

Answer 31

Chronic granulomatous disease