Immunology and Allergy Flashcards
Region comprises several genes implicated with allergic disease pathogenesis
5Q23-25
DOC for Persistent Mod-Severe AR
Intranasal CS
Block of development from pre B cell to B cell
Bruton Disease
Bruton Disease Ig
< 250
Oral thrush, Depressed Igs
SCID
Aberrant Thymus, Susceptible to infection
DiGeorge Syndrome
CATCH 22
Cardiac Defect Abnormal Facies Thymic aplasia Cleft Palate Hypocalcemia 22q11.2
Asthmatic mother, eczematous rash in extensors (very young), flexors (older kids)
Atopic dermatitis
Immunodeficiency with Thromocytopenia and Eczema
Wiskott - Aldrich Syndrome
Tx for Wiskott Aldrich
BM/ Cord Blood Transplantation
Gene for Wiskot Aldrich
WASP
Gold Standard for Diagnosis of food allergy
Double Blind Placebo controlled Food challenge
No production of B Cells
Bruton’s
Low IgG with Normal B cells, Inc risk of granuloma
CVID
Low or absent IgA
Selective IgA deficiency
Dec IgG, IgA, IgE, N/Inc IgM
Hyper IgM syndrome
Lack of anti EBNA, Long lived T Cell immunity
Duncan disease
Fatal infectious mononucleosis
Duncan Disease
Giardiasis
Selective IgA def
P. jiroveci pneumonia
Hyper IgM
Treatment for B Cell defects
IVIG 400 mg/month
Low T Cells, CATCH 22
DeGeorge
Treatment for T Cell immunodeficiency
Thymic transplant
Absence of B and T Cells, Opportunistic Inf
SCID
T cell def, Thromobcytopenia
Wiskott Aldrich
Coarse Facies, Pathologic fractures, Aspergillus
Hyper IgE (AD)/ Job Syndrome
Higher incidence of Lymphoma
Hyper IgE (AR)
Disordered coalescence of Lyosomal Granules
Chediak Higashi
Oculocutaneous albinism, Light skin and silvery hair, Rotary Nystagmus
Chediak Higashi
Impaired neutrophil adhesion and activation, decreased binding to C3Bi, Bac infection with lack of pus formation
Leukocyte adhesion deficiency
Defect in generation of microbicidal oxygen metabolites
Chronic granulomatous disease
