Immunology Flashcards
describe the innate immune system
immediate
non-specific
no memory
describe the adaptive immune system
later
specific
memory
what are the main APC in the external eye
Langerhans cells
Langerhans cells have a lot of class I/II MHC molecules
class II
where in the eye are Langerhans cells found
corneo-scleral limbus
get less as you move to the centre of the cornea
the conjunctiva are the only part of the eye with lymphatic drainage, true or false
true
what APC are found in the conjunctiva
dendritic cells
what is MALT and where is it found
mucosal associated lymphatic tissue
conjunctiva
instead of lymph nodes
the cornea and sclera are a/vascular and don’t/have lymphoid tissue
avascular
don’t have lymphoid tissue
what immune mechanisms/cells does the lacrimal gland have
IgA and CD8+ T cells
MALT
where is the blood ocular barrier found
choroid and retina
which parts of the body have immune privilege
eyes
testes
brain
placenta/foetus
what is immune privilege
sites of the body with immune privilege are able to tolerate the introduction of an antigen without initiating an immune response
what does ACAID stand for
Anterior Chamber Associated Immune Deviation
what is ACAID
placement of a foreign material into the ocular microenvironment can induce a systemic form of tolerance to this material i.e. peripheral tolerance to ocular antigen
