Immunology

Question 1

SHiN + GI (giardia)

Answer 1

Probably B cell disorder
X linked agammaglobulinemia (Brutons) low B cells + all Igs
CVID nl B cells, low IgG +- A, M
Hyper IgM, low other Igs (x-liked, CD40 no class switching + opportunistic and viruses)
Hyper IgE, nl others
Selective IgA def (anaphylaxis w tfusion, autoimmune probs)
Tx IVIG

Question 2

viral, fungal, opportunistic

Answer 2

SCID
Low Ts and Bs
tx stem cell tplant

Question 3

Catalase+ organisms (staph, serratia)

Answer 3

Oxidative burst chronic granulomatous disease
Dihydrorotamine 123
Nitroblue

Question 4

CD19

Answer 4

B cells

Question 5

CD3

Answer 5

T cells

Question 6

Contraindication for rotavirus vacc

Answer 6

Intussusception

Question 7

Hereditary angioedema

Answer 7

AD, C1 inh def high C4

Question 8

SHiN but no GI

Answer 8

Complement deficiency

CH50 measures total complement

Question 9

Staph + anaerobes

Answer 9

Leukocyte adhesion deficiency
Delayed umb separation > 3 w
NON PURULENT
high leuks, very high neutrophils

Question 10

Chickenpox that doesn’t resolve

Answer 10

T cell dysfunction