Immunology Flashcards
Antigen Presenting Cells
Macrophages, Monocyte, Neutrophiles, Eosinophils, Basophils
Eosinophils
Parasitic and allergic reactions
Which APC is not phagocytic
Basophils
Which APC is most common
Neutrophils
Laugerhan
Macrophages in the skin
T-cells
Specific lymphocytes. Divide into Helper (CD4) and T cytotoxic (CD8)
B-cells
Specific lymphocytes. Make plasma cells which make AB.
Natural Killer Cells
Non specific lymphocytes. Do not need APC.
FAB portion of AB
bind antigens. Has a light and heavy chain
FC potion of AB
compliment and constant portion
Kupffer cells
APC in the liver
Non specific Immunity
Natural killer, interferon, Compliment (IgG, IGA, IGM)
What is the first thing to arrive with infection
Neutrophils (PMN)s.
What makes pus (suppuration)
PMNs
Which cells are PMNs
BEN. Basophils, neutrophils, eosinophils.
What do PMNs release
Granulocytes full of proteolytic enzymes that break down antigens
Interferon
Nonspecific and increased in viral infections
Beta interferon
Used for MS
Alpha Interferon
Used for Hepatitis C.
What does complement pathway do
CODD. Chemotaxis of neutrophils and macrophages, Opsonization, Degranulation of mast cells, direct lysis of bacteria
Classic Complement pathway
GM motors. IgG, IGM.
Alternative complment pathway
IgA and bacterial endotoxins.
In laments terms what is Specific immunity
T cells telling B cells to make specific AB
Where are B and T lymphocytes made
Bone
Where do T lymphocytes mature
thymus
where do B lymphocytes mature
Bone marrow
Steps of Specific immunity
APC, Antigen must match, Receptors must match
T helper cell has what receptor and who do they match
CD4 and match MHC II
T killer cells have what receptor and who do they match
CD8 and match MHC I
What happens after Macrophage matches with T-helper cell?
Sends IL-1 to T helper cell. Then T-helper cell sends IL-2 to B cells to create Ab
When do Killer T cells work
Viral infections
What does restates do?
Stops new release of IL2
Type 4 hypersensitivty
Mediated by T killer cells.
Haptin
Happens with Type 4 and T killer. SO small must bind protein for a reaction.
Who do we order ANA for?
Lupus or other autoimmune.
