Immunology

Question 1

HLA A3

Answer 1

Hemochromatosis

Question 2

HLA B27

Answer 2

PAIR

• Psoriatic arthritis
• Ankylosing Spondylitis
• Inflammatory Arthritis
• Reactive Arthritis (Reiter Syndrome)

Question 3

HLA DQ2/DQ8

Answer 3

Celiac Disease

Question 4

HLA DR2

Answer 4

• MS
• Hay fever
• SLE
• Goodpasture’s syndrome

Question 5

HLA DR3

Answer 5

• DM1
• SLE
• Grave’s disease
• Hashimoto thyroiditis

Question 6

HLA DR4

Answer 6

Rheumatoid Arthritis, DM1

Question 7

HLA DR5

Answer 7

• Pernicious Anemia
  
  • leads to Vitamin B12 deficiency
• Hashimoto thyroiditis

Question 8

Pure B-cell disorders:

Answer 8

1. X-linked (Bruton) agammaglobulinemia
2. Selective IgA deficiency
3. CVID

Question 9

Pure T-cell disorders:

Answer 9

1. Thymic aplasia (DiGeorge syndrome)
2. IL12-receptor deficiency
3. Autosomal dominant hyper IgE syndrome (Job syndrome)
4. Chronic mucocutaneous candidiasis

Question 10

B and T cell disorders:

Answer 10

1. SCID
2. Ataxia-telengiectasia
3. Hyper-IgM syndrome
4. Wiskott-Aldrich syndrome

Question 11

Phagocyte dysfunction:

Answer 11

1. Leucocyte adhesion deficiency (LAD) type 1
2. Chediak-Higashi syndrome
3. Chronic granulomatous disease (CGD)

Question 12

What is the most common primary immunodeficiency?

Answer 12

Selective IgA deficiency

Question 13

What is deficient in heriditary angioedema?

Answer 13

C1 esterase inhibitor deficiency

Question 14

What are the features of C3 deficiency?

Answer 14

• severe, recurrent pyogenic sinus and respiratory tract infections
• ↑ susceptibility to type III hypersensitivity

Question 15

What are the features of C5-C9 deficiencies?

Answer 15

↑ susceptibility to recurrent Neisseria bactermia

Question 16

What does DAF (GPI-anchored enzyme) deficiency lead to?

Answer 16

• Complement-mediated lysis of RBCs
• Paroxysmal nocturnal hemoglobinuria (PNH)