Immunology Flashcards
Name the cytokines secreted by macrophages?
IL-1, 6, 8, 12, TNF-alpha
IL-1
endogenous pyrogen, activates endothelium to produce adhesion molecules
IL-6
endogenous pyrogen, causes production of acute phase proteins
also secreted by Th2
IL-8
major chemotatic factor for neutrophils
others are c5a, LTB4 and bacterial products
IL-12
induces Th0 -> Th1, activates NK cells
also secreted by B cells
TNF-alpha
mediator of toxic shock
activates endothelium and recruits neutrophils
Name the cytokines released by all T cells?
IL-2, 3
IL-2
induces T cell proliferation
IL-3
supports growth and differentiation of myeloid lineage cells in the bone marrow
3 turned on its side is an ‘m’ -> 3 goes to myeloid
Name the cytokines released by Th1 cells?
INF-gamma
INF-gamma
increases expression of MHC and antigen presenting on all cells, increases NK killing of virally infected cells
enhances macrophage activity (treatment for CGD)
inhibits Th2 cells
Name the cytokines secreted by Th2 cells?
IL-4,5,6,10
IL-4
induces Th2 differentiation class switching to IgE and IgG
IL-5
class switching to IgA stimulates growth of eosinophils
IL-10
inflammatory modulator; inhibits actions of Th1 cells
generally anti-inflammatory
also secreted by Tregs
