Immunology 3 Flashcards
Where do B cells mature?
Primary lymphoid tissues - bone marrow and spleenW
What is the function of B cells?
Produce antibodies that attack pathogens circulating in blood and lymph
What are antibodies?
Proteins that bind to one specific antigen
What is an adaptive immune response induced by?
Antigens
What is an antigen?
Any substance which can cause an adaptive immune response by activating B cells and T cells
How many copies of an antibody are expressed by one B cell?
Over 50,000
What are secondary lymphoid tissues?
Where T and B cells are activated by antigens
What are some secondary lymphoid tissues?
Lymph nodes, spleen and mucosal - associated lymphoid tissues
What are the lymph nodes important for?
Monitoring tissue infections
What is the spleen important for?
Monitoring blood-borne infections
What are the mucosal-associated lymphoid tissues important for?
Monitoring throat/ GI tract infections
How do B and T cells enter lymph nodes?
Through HEVs, high endothelial venules
Where do B cells go when they immediately enter the lymph node?
Lymphoid follicle
Where do T cells go when they immediately enter the lymph node?
They stay in the T-cell area of the lymph node and interact with dendritic cells which enter by afferent lymph
How do both lymph and lymphocytes leave the node and re-enter the circulatory system?
First through the medullary sinus then by efferent lymphatic vessels. They re-enter the blood stream via the subclavian vein.
