Immunology Flashcards
What are the 3 layers of the lymph node?
What is found in each layer?
Cortex - B cells (follicles)
Paracortex - T cells
Medulla - lymphocytes (macrophages)
The spleen is located behind which ribs?
9-11th ribs
What are the 3 areas/zones of the spleen?
What is found in the zones?
White pulp - WBCs
Marginal zone - macrophages, specialized B cells
Red pulp - RBCs
What are important histological features after a splenectomy?
Howell-Jolly bodies
Target cells
Thrombocytosis and lymphocytosis
What is the thymus?
The site of T cell maturation. It involutes by 3 years old
What diseases are associated with an absent thymus?
DiGeorge Syndrome and SCID
What are the 3 HLA subtypes for MHC1?
HLA A, B, and C
What are the 3 HLA subtypes for MHCII?
HLA - DP
HLA - DQ
HLA - DR
What is the sequence for antigen-MHCI loading?
- Antigen and MHCI are loaded in the RER
- The complex is processed and trafficked through the Golgi
- Complex fuses with the plasma membrane
What is the sequence for loading MHCII with antigen?
- Antigen enters the cell
- Antigen and MHCII are loaded inside of the phagolysosome
- Fusion with plasma membrane
Which cell is used to initiate class switching of B-cells?
Th2 cells. They release either IL-4 or IL-5 to the B cell
The B7 receptor on an APC binds to what receptor on T cells?
CD28
What antibodies are expressed on all Naiive B cells?
IgM and IgD
Which antibody can cross the placenta?
IgG
Which antibody is produced in GI peyer patches?
IgA
Which cells are involved in type 4 hypersensitivity reactions?
T cells
Which cells are involved in acute and chronic organ rejections?
T cells
