Free 120 Flashcards
Type 2 pneumocytes function
Secrete surfactant
Serve as stem cells to make type I and type 2 cells
Sarcoidosis pathophysiology
Granulomatous disorder that effects calcium homeostasis due to overactivation of macrophages and increased renal production of vitamin D
Are there noncaseating or caseating granulomas in sarcoidosis?
Non-caseating granulomas, widespread
Pheochromocytomas are found in MEN1 or MEN2
MEN 2
RET is a tumor suppressor or protooncogene
protooncogene
Its a receptor tyrosine kinase
Think growth
MEN1 mutation (menin, chromosome 11) is a tumor suppressor or protooncogene
tumor suppressor (2 hit)
Medullary thyroid cancer is neoplasm of what kind of cells?
parafollicular - calcitonin
Fremitus is increased in what situation
When there is consolidation like a lobar pneumonia
Function of leptin
Satiety, decreases appetite
Obese people have increased or decreased leptin
Increased because leptin is secreted by adipose tissue
Describe Type I error
Stating that there is a difference when none exists
Describe type II error
Stating there is not a difference when there is
Bronchiectasis is obstructive or restrictive
Obstructive
Chronic cough and daily sputum production
Associated with cystic fibrosis
Rifampin changes warfarin metabolism in what way?
It is a CYP450 inducer = warfarin gets metabolized more quickly and it doesn’t work as well = low INR
Which lab technique is best for detecting viral RNA/DNA
Reverse transcription PCR0
Which antibiotic class is best used for pertussis?
Macrolides
Method of action of terbinafine (tinea pedis treatment)
Inhibition of squalene monooxygenase which disrupts ergosterol synthesis (fungal cell membranes)
Opening pressure is increased in bacterial, fungal, or viral meningitis
All but viral is closer to normal
Glucose is low in bacterial, fungal, or viral meningitis?
Bacterial and fungal.
It is normal in viral
Compare hemidesmosomes and desomosomes
Desmosomes connect cells side to side
Hemidesmosomes connect cells to the basement membrane
Autoantibodies to desmosomes result in what skin condition
Pemphigus vulgaris