Immunology 🤺

Question 1

Complement function

Answer 1

Neut chemotaxis-C5a
Cytolysis -MAC - C5-9
Opsonization -C3b
Anaphylaxis - C3/4a

Question 2

Nitric Oxide

Answer 2

Vasodilation
Hypotension
Shock
NO can be released from bac toxin
Not seen in anaphylaxis

Question 3

which cell releases r IFN ?
Function ?

Answer 3

Tymphocyte
Activates Mphage to kill tumor cell

Question 4

IL-4

Answer 4

Naive T cell - Th1 differentiation
B cells - proliferation + Ig Class switching
Eg: IgE - Allergy

Question 5

IL-5

Answer 5

Ig A
Mucosal immunity
Esonophil activity - parasite infection

Question 6

IL-3

Answer 6

Produced by T cells
BM Stem cells Growth and proliferation

Question 7

IL-2

Answer 7

First IL after contact with antigen

Question 8

IL10

Answer 8

Regulate the population balance between Th1 and Th2
Inhibit IFN-r - decrease Th1 cell
From Ig M to Ig G

Question 9

IL-12

Answer 9

Growth and development of Th1 cells

Question 10

What cell produce IFN -r ?

Answer 10

NK
T cells

Question 11

Function of IFN-r

Answer 11

In response to Viral and bac infection
Mф activation
Increase MHC expression
Increase Th2 expression

Question 12

Secondary swelling /tissue damage in Allerguc reaction due to

Answer 12

Protein produced by esinophil in response to LT/His release from mast cell

Question 13

Which complement is opsonin

Answer 13

C-3b

Question 14

Chemotactic agents

Answer 14

C-5a
LTB4
5HETE
IL-8
Function : Neut chemotaxis/ phagocytosis

Question 15

Complement pathway

Answer 15

1. Mannose -lecithin + C1
2. Classical -IgG +C1
3. Alternative -C3

Question 16

Which complement is anaphylaxis

Answer 16

C3a

Question 17

Common Cause of complement deficiency

Answer 17

Autoantibodies induced classical pathway activation
Complement consumption increases (low C4/C3)
CH50 -measure functional activity of C
SLE /RA/Skin ds