Immunology Flashcards
Some Persian are predisposed to Chédiak-Higashi syndrome. What is their coat color (one word) ?
smoke
Which one of these diseases does not lead to immunodeficiency?
* Chédiak-Higashi syndrome
* Cyclic hematopoiesis
* Lethal acrodermatitis
* Leukocyte adhesion deficiency
Chédiak-Higashi syndrome
Morphological leukocyte change causing no immunodeficiency but leading to a bleeding tendency following platelet sotrage pool disease
Some Collies are predisposed to cyclic hematopoiesis. What is their coat color (one word) ?
grey
Which breed of cats is predisposed to a morphological abnormality in leukocytes ?
* Burmese
* Birman
* Brittish shorthair
* Burmilla
Birman
Acidophilic granulation of leukocytes
Leukocyte Adhesion Deficiency is secondary to:
* CD18 deficiency
* E-selectin deficiency
* CXCL8R deficiency
* C3 deficiency
CD18 deficiency
CD11/18 is an heterodimer that is essential for leucocyte adhesion to endothelium membrane once activated (ie through binding to ICAM-1). E-selectin is an endothelial integrin that allows leukocytes rolling. CXCL8R is IL-8 receptor that serves for signaling during adhesion.
Irish and red and white setters are predisposed to:
* Leukocyte adhesion deficiency
* Complement component 3 deficiency
* Bactericidal neutrophil defect
* Combined immunodeficiency
Leukocyte adhesion deficiency
- Complement component 3 deficiency > Brittany spaniel (one research colony)
- Bactericidal neutrophil defect > Doberman pinscher
- Combined immunodeficiency -> Sharpei
Congenital cobalamin deficiency is reported in:
* Australian cattle dog
* Australian shepherd
* Airedale terrier
* Basset hound
Australian shepherd
- Giant schnauzers
- Beagles
- Australian shepherd
- Komondor
- Border collie
Trapped neutrophil syndrome is reported in:
* Border collie
* Bearded colley
* Cardigan Welsh Corgi
* Basset hound
Border collie
Cardigan Welsh Corgi and Basset hound : X-linked severe combined immunodeficiency (research colonies)
Give 5 criteria for SLE diagnosis
ANA
mucocutaneous lesions
Arthritis
Renal disorders
Anemia and/or thrombocytopenia
Leukopenia
Polymyositis or myocarditis
Serositis
Neurologic disorders
Antiphospholipid antibodies
Cite infectious diseases known to be associated with positive ANA titers
Leishmaniasis, FIV, FeLV, Bartonellosis. Can also be present in dogs with neoplastic disease and with a low prevalence in healthy dogs. ANA negative SLE have been described in humans and dogs
Which breeds are predisposed to Prototheca infection ?
Boxer and Collies, suggesting an underlying neutrophil defect
Which infection is identified in dogs with Common Variable Immunodefiency ? Which breeds are concerned ?
Pneumocystis carinii. CKCS, miniature Daschund.
Which breeds are predisposed to CPV ?
Rottweiler, GSD, Doberman Pinscher
