Immunoglobulins Flashcards

1
Q

IgD structure

A

Monomer

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2
Q

IgE structure

A

Monomer

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3
Q

IgG structure

A

Monomer

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4
Q

IgM structure

A

Pentamer with J chain

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5
Q

IgA subclasses

A

2 (a1, a2)

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6
Q

IgD subclasses

A

None

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7
Q

IgE subclasses

A

None

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8
Q

IgE subclasses

A

None

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9
Q

IgG subclasses

A

y1-4

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10
Q

IgM subclasses

A

None

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11
Q

IgA found in

A

Secretions (saliva, tears, breast milk)
Intestinal fluids
Serum

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12
Q

IgD found in

A

On surface of B cells

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13
Q

IgE found in

A

Blood

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14
Q

IgG found in

A

Blood: intravascular and extravascular spaces

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15
Q

IgM found in

A

Blood: intravascular spaces

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16
Q

IgA bio activity

A

In secretions it protects against foreign antigens

17
Q

IgD bio activity

A

Basically unknown, but thought to play a role in antigen binding in association with IgM and B-cell activation

18
Q

IgE bio activity

A

Binds to mast cells and basophils mediating release of histamine and heparin
Plays a role in helminth infections

19
Q

IgG bio activity

A

Neutralize toxins, activates complement, crosses placenta, agglutination, opsonization

20
Q

IgM bio activity

A

Complement activation and agglutination

21
Q

IgA structure

A

Monomer and dimer with j chain