Immunoglobulins Flashcards
IgD structure
Monomer
IgE structure
Monomer
IgG structure
Monomer
IgM structure
Pentamer with J chain
IgA subclasses
2 (a1, a2)
IgD subclasses
None
IgE subclasses
None
IgE subclasses
None
IgG subclasses
y1-4
IgM subclasses
None
IgA found in
Secretions (saliva, tears, breast milk)
Intestinal fluids
Serum
IgD found in
On surface of B cells
IgE found in
Blood
IgG found in
Blood: intravascular and extravascular spaces
IgM found in
Blood: intravascular spaces
IgA bio activity
In secretions it protects against foreign antigens
IgD bio activity
Basically unknown, but thought to play a role in antigen binding in association with IgM and B-cell activation
IgE bio activity
Binds to mast cells and basophils mediating release of histamine and heparin
Plays a role in helminth infections
IgG bio activity
Neutralize toxins, activates complement, crosses placenta, agglutination, opsonization
IgM bio activity
Complement activation and agglutination
IgA structure
Monomer and dimer with j chain
