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SI > Cytokines > Flashcards

Cytokines Flashcards

1
Q

INF A and B target cells?

A

NK cells

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2
Q

INF Y produced by?

A

T helper cells

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3
Q

INF Y target

A

Macrophages, cytotoxic T cells, NK cells

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4
Q

INF A, B, Y Biologic activity?

A 
Antiviral activity,
Mediates MHC class I amd II expression
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5
Q

TNF A produced by?

A

Macrophages, gram negative bacteria

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6
Q

TNF A target

A

Macrophages, mast cells

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7
Q

TNF A biologic activity

A

Mediates inflammation by recruiting and activating phagocytes

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8
Q

TNF B produced by?

A

Epithelial cells

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9
Q

TNF B target?

A

T Cells and B cells

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10
Q

Also known as lymphotoxin?

A

TNF B

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11
Q

IL-1 produced by

A

Monocytes, macrophges

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12
Q

IL-1 target

A

Hypothalamus, epithelial cells

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13
Q

IL-1 biologic actovity

A

Acute phase rections, mediate cell adhesion for diapedesis

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14
Q

IL-2 produced by

A

T helper cells

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15
Q

IL-2 target

A

Tcells and Bcells

Macrophages

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16
Q

IL-2 biologic actovity

A

Growth and differentiation of T cells and B cells, activtes monocytes, macrophages, and NK and cytotoxic cells

17
Q

IL-4 produced by

A

Naive t cells and t helper cells

18
Q

IL-4 target

A

T cells

19
Q

IL-4 biologoc actovity

A

Induces growth of Thelper cells, mediates humoral immunity

20
Q

IL-5 produced by

A

T helper cells

21
Q

IL-5 target

A

Eosinophils, B cells

22
Q

IL-5 biologic activity

A

Growth of eosinophils, mediator of type 1 hypersensitivoty reactions

23
Q

IL -6 produced by

A

T cells, B cells, monocytes, macrophages, other nonimmune cells

24
Q

IL-6 target

A

B cells, t cells

25
Q

IL-6 biologic activity

A

Acute phase reactions, antibody production, stimulates B cells to plasma cells

26
Q

IL-10 produced by

A

Monocytes, macrophages, T cells

27
Q

IL-10 target

A

T helper cells, antigen precenting vells

28
Q

IL-10 biologic activity

A

Antiinflammatory and suppresive effect

29
Q

Transforming growth factor / TGF - B produced by?

A

T-regulatory cells

30
Q

TGF -B target

A

T cells, B cells

31
Q

TGF-B biologic activity

A

Activates and inhibits proliferation, regulates inflammatory response

32
Q

Colony stimulating factor (CSFs) produced by

A

T Cells

33
Q

CSFs target

A

Bone marrow stem cells

34
Q

CSFs biologic activity

A

Stimulate hematopoietic stem cell differentiation of grnulocytes, macrophages

35
Q

Interferon A and B are produced by?

A

Virally infected dendritoc cella

SI (8 decks)

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