Cytokines Flashcards
INF A and B target cells?
NK cells
INF Y produced by?
T helper cells
INF Y target
Macrophages, cytotoxic T cells, NK cells
INF A, B, Y Biologic activity?
Antiviral activity, Mediates MHC class I amd II expression
TNF A produced by?
Macrophages, gram negative bacteria
TNF A target
Macrophages, mast cells
TNF A biologic activity
Mediates inflammation by recruiting and activating phagocytes
TNF B produced by?
Epithelial cells
TNF B target?
T Cells and B cells
Also known as lymphotoxin?
TNF B
IL-1 produced by
Monocytes, macrophges
IL-1 target
Hypothalamus, epithelial cells
IL-1 biologic actovity
Acute phase rections, mediate cell adhesion for diapedesis
IL-2 produced by
T helper cells
IL-2 target
Tcells and Bcells
Macrophages
IL-2 biologic actovity
Growth and differentiation of T cells and B cells, activtes monocytes, macrophages, and NK and cytotoxic cells
IL-4 produced by
Naive t cells and t helper cells
IL-4 target
T cells
IL-4 biologoc actovity
Induces growth of Thelper cells, mediates humoral immunity
IL-5 produced by
T helper cells
IL-5 target
Eosinophils, B cells
IL-5 biologic activity
Growth of eosinophils, mediator of type 1 hypersensitivoty reactions
IL -6 produced by
T cells, B cells, monocytes, macrophages, other nonimmune cells
IL-6 target
B cells, t cells
IL-6 biologic activity
Acute phase reactions, antibody production, stimulates B cells to plasma cells
IL-10 produced by
Monocytes, macrophages, T cells
IL-10 target
T helper cells, antigen precenting vells
IL-10 biologic activity
Antiinflammatory and suppresive effect
Transforming growth factor / TGF - B produced by?
T-regulatory cells
TGF -B target
T cells, B cells
TGF-B biologic activity
Activates and inhibits proliferation, regulates inflammatory response
Colony stimulating factor (CSFs) produced by
T Cells
CSFs target
Bone marrow stem cells
CSFs biologic activity
Stimulate hematopoietic stem cell differentiation of grnulocytes, macrophages
Interferon A and B are produced by?
Virally infected dendritoc cella
