Immunoglobulins

Question 1

Igs synthesized by

Answer 1

Cells of B lymphocyte

Question 2

2 forms of Igs

Answer 2

Membrane-bound ab( Ig)— function as ag receptors
Secreted ab(Ig)— function to protect against microbes

Question 3

2 regions of Igs

Answer 3

Variable regions
Constant regions

Question 4

Variable region structures

Answer 4

Light chain
CDRs— complement determining region

Question 5

Constant region structures

Answer 5

Heavy chain

Question 6

Which parts are variable among Igs

Answer 6

Regions that bind antigens

Question 7

Symmetric core structure of antibody

Answer 7

2 identical heavy chains
2 identical light chains

Question 8

Ig-like structures

Answer 8

TCR
Class 1 MHC
CD4
CD28
ICAM-1

Question 9

Antibody heavy chains and light chains both consist of

Answer 9

Amino-terminal variable (V) regions— participate in ag recognition
Carboxy-terminal (C) regions

Question 10

Which region of Igs is the ag binding portion

Answer 10

Fab

Question 11

Which portion of Ig is involved in the effector functions

Answer 11

Fc region

Question 12

Two types of light chains

Answer 12

κ
λ
Each B cell expresses either κ or λ not both

Question 13

5 types of heavy chains

Answer 13

μ
δ
γ
ε
α

Question 14

Which enzyme digest the Fab region end makes 2 Fab and 1 Fc region

Answer 14

Papain

Question 15

Which enzyme changes the Hinge region and results with 1 F(ab’)2 and peptide products

Answer 15

Pepsin

Question 16

Isotopes of ab

Answer 16

IgA
IgD
IgE
IgG
IgM

Question 17

Function of IgA

Answer 17

Mucosal immunity
Main ab that found in breast milk

Question 18

Functions of IgD

Answer 18

Naive B cell ag receptor

Question 19

Functions of IgE

Answer 19

Mast cell activation— immediate hypersensitivity
Defense against helminthic parasites

Question 20

Functions of IgG

Answer 20

Opsonization
Complement activation
Ab dependent cell-mediated cytotoxicity
Neonatal immunity
Feedback inhibition of B cells

Question 21

Functions of IgM

Answer 21

Naive B cell ag receptor
Complement activation

Question 22

Which Ig passed from the placenta

Answer 22

IgG

Question 23

Viral infections result with which type of cytotoxicity

Answer 23

Ab-dependent cytotoxicity

Question 24

Recognition of bacteria done by

Answer 24

1-Self
2-Fc Ab
3- Complement C3b Fc Ab

Question 25

Bacteria engulfment done by

Answer 25

1-PAMPR-PRR—> TLRs
2- Opsonization —> Fc recognition
3- Complement—> CD3

Question 26

Flexibility of ab molecules provides

Answer 26

Flexibility due to the hing regions
Permit independent movement of ag-binding sites relative to the rest of the molecule

Question 27

Types of changes in ab structure

Answer 27

Affinity maturation — somatic mutations in variable region
Changed from membrane to secrete from
Isotope switching

Question 28

Parts of the antigen that recognized by the antibodies called

Answer 28

Epitopes