Antigen Capture And Presentation To Lymphocytes Flashcards
Adaptive immune responses are initiated by
Recognition of ag by ag receptors of lymphocytes
The types of antigens that T lymphocytes recognize
Only peptide recognition
Only when presented by MHC
Which cells uptake the antigen in order to present it to T cells
Dendritic cell
Macrophage
B cell
Which cell ag presentation results with naive T cell activation
Dendritic cells
Which cell antigen presentation results with effector T cell activation
Macrophage— cell mediated immunity
B cell — humoral immunity
Where is antigen being taken If an antigen enter the bloodstream?
Captured by?
Spleen — captured by APCs
Where is antigen being taken if antigen entered through skin,GIT,respiratory tract?
Captured by?
Lymph node— captured by dendritic cells
What happens when DCs capture ag that enter through the epi
Immature DCs capture the ag
Transport ag to LN
During migration immature DCs mature and become efficient APCs
What are the MHCs
Membrane proteins on APCs that display peptide ag for recognition by T lymphocytes
MHC expressing cell types
Dendritic cells
Macrophages
B cells
How is the broad specificity of MHC
Many different peptides can bind to the same MHC molecule
Which MHC pathway does endocytosis/ extracellular protein uses
MHC 2
CD4+T cell
Which MHC pathway does Cytosolic protein uses
MHC 1
CD8+ CTL
In Class 2 MHC pathway which cells expresses that MHC
Endothelial cells
Thymus epithelium
In class 1 MHC pathway which cells expresses that MHC
All nucleated cells
