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Host Defense > Immunoglobulin Structure Lecture 4 > Flashcards

Immunoglobulin Structure Lecture 4 Flashcards

1
Q

How do Ig classes differ?

A

constant region in the heavy chain

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2
Q

What is the structure of IgM?

A

pentameric IgM

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3
Q

What is the secretory structure of IgA?

A

Dimeric

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4
Q

What is the secretory component of the IgA?

A

protective hinge area where the dimer might be cleaved

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5
Q

What is the major immunoglobin in blood?

A

IgG

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6
Q

Where do you find IgD immunoglobins?

A

on surface of b-cells

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7
Q

What is a baby born with?

A

Maternal IgG

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8
Q

What does cross linking of IgE on mast cells lead to?

A

Degranulation, histamine and other substances released that cause allergic reactions
*must be crosslinked

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9
Q

What are 3 methods by which antibodies mediate humoral immunity?

A
  1. Neutralization-prevent bacterial adhesion
  2. Opsonization-antibody promotes phagocytosis
  3. Complement Activation-antibody activates complement, enhances opsonization and lyses bacteria
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10
Q

IgM, primary or secondary response?

A

Primary

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11
Q

IgG, primary or secondary response?

A

Secondary

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12
Q

IgD usually membrane form or plasma form?

A

membrane

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13
Q

What does aggregation of immunoglobulin on bacterial surface allow for?

A
  • cross linking of Fc receptors
  • activation of macrophage
  • phagocytosis and destruction of bacterium
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14
Q

What is a crucial time for babies, because maternal IgG antibody is almost gone and they havent started making much of its own IgG?

A

3-9 months

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15
Q

Is a vaccine as good as having the disease in terms of half life length of serum antibody?

A

NO

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16
Q

Polyclonal vs. Monoclonal antibodies

A

Polyclonal: multiple antibodies, directed against different epitopes made by separate clones of B-lymphocytes
ex: IVIG (intravenous immunoglobin)treatment for inflammatory disease

Monoclonal: single B-cells that make a single kind of antibody, can be immortilized in vitro and used as a continual source of a specific monoclonal antibody
ex: tumor specific antibodies to treat cancer

17
Q

What type of rearrangement do Ig genes undergo?

A

somatic DNA recombination

18
Q

What exons encode the variable region in the light chain?

A

V and J exons

19
Q

What exon encodes the constant region in the light chain?

A

a C exon

20
Q

What exons encode the variable region in the heavy chain?

A

V, D, J exons

21
Q

What exon encodes the constant region of the heavy chain?

A

multiple C exons

membrane associated: transmembrane and cytoplasmic

22
Q

Where are Ig genes only expressed?

A

B-lineage cells

23
Q

what is the order of Ig gene rearrangement
light chain
heavy chain

A
  1. heavy chain DJ
  2. heavy chain VDJ (critical control point)
  3. light chain VJ

Host Defense (11 decks)

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